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MicroRNA-34a: a potential therapeutic target in human cancer
MicroRNAs (miRs) are small noncoding RNAs that negatively regulate gene expression by binding to the three untranslated regions of their target mRNAs. Deregulations of miRs were shown to play pivotal roles in tumorigenesis and progression. Recent research efforts have been devoted to translating the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123066/ https://www.ncbi.nlm.nih.gov/pubmed/25032850 http://dx.doi.org/10.1038/cddis.2014.270 |
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author | Li, X J Ren, Z J Tang, J H |
author_facet | Li, X J Ren, Z J Tang, J H |
author_sort | Li, X J |
collection | PubMed |
description | MicroRNAs (miRs) are small noncoding RNAs that negatively regulate gene expression by binding to the three untranslated regions of their target mRNAs. Deregulations of miRs were shown to play pivotal roles in tumorigenesis and progression. Recent research efforts have been devoted to translating these basic discoveries into applications that could improve the therapeutic outcome of patients with cancer. MiR-34a is a highly conserved miR throughout many different species. In humans, there are three homologs (hsa-miR34a, hsa-miR-34b and hsa-miR-34c). Early studies have shown that miR-34a acts as a tumor-suppressor gene by targeting many oncogenes related to proliferation, apoptosis and invasion. In this review, we provide a complex overview of miR-34a, including regulating its expression, its known functions in cancer and future challenges as a potential therapeutic target in human cancers. |
format | Online Article Text |
id | pubmed-4123066 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-41230662014-08-15 MicroRNA-34a: a potential therapeutic target in human cancer Li, X J Ren, Z J Tang, J H Cell Death Dis Review MicroRNAs (miRs) are small noncoding RNAs that negatively regulate gene expression by binding to the three untranslated regions of their target mRNAs. Deregulations of miRs were shown to play pivotal roles in tumorigenesis and progression. Recent research efforts have been devoted to translating these basic discoveries into applications that could improve the therapeutic outcome of patients with cancer. MiR-34a is a highly conserved miR throughout many different species. In humans, there are three homologs (hsa-miR34a, hsa-miR-34b and hsa-miR-34c). Early studies have shown that miR-34a acts as a tumor-suppressor gene by targeting many oncogenes related to proliferation, apoptosis and invasion. In this review, we provide a complex overview of miR-34a, including regulating its expression, its known functions in cancer and future challenges as a potential therapeutic target in human cancers. Nature Publishing Group 2014-07 2014-07-17 /pmc/articles/PMC4123066/ /pubmed/25032850 http://dx.doi.org/10.1038/cddis.2014.270 Text en Copyright © 2014 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/3.0/ Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Review Li, X J Ren, Z J Tang, J H MicroRNA-34a: a potential therapeutic target in human cancer |
title | MicroRNA-34a: a potential therapeutic target in human cancer |
title_full | MicroRNA-34a: a potential therapeutic target in human cancer |
title_fullStr | MicroRNA-34a: a potential therapeutic target in human cancer |
title_full_unstemmed | MicroRNA-34a: a potential therapeutic target in human cancer |
title_short | MicroRNA-34a: a potential therapeutic target in human cancer |
title_sort | microrna-34a: a potential therapeutic target in human cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123066/ https://www.ncbi.nlm.nih.gov/pubmed/25032850 http://dx.doi.org/10.1038/cddis.2014.270 |
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