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CHOP mediates ASPP2-induced autophagic apoptosis in hepatoma cells by releasing Beclin-1 from Bcl-2 and inducing nuclear translocation of Bcl-2
Apoptosis-stimulating protein of p53-2 (ASPP2) induces apoptosis by promoting the expression of pro-apoptotic genes via binding to p53 or p73; however, the exact mechanisms by which ASPP2 induces apoptotic death in hepatoma cells are still unclear. Here, we show that the transient overexpression of...
Autores principales: | Liu, K, Shi, Y, Guo, X, Wang, S, Ouyang, Y, Hao, M, Liu, D, Qiao, L, Li, N, Zheng, J, Chen, D |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123070/ https://www.ncbi.nlm.nih.gov/pubmed/25032846 http://dx.doi.org/10.1038/cddis.2014.276 |
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