Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L

Caspase-2 represents the most conserved member of the caspase family, which exhibits features of both initiator and effector caspases. Using ribonucleoprotein (RNP)-immunoprecipitation assay, we identified the proapoptotic caspase-2L encoding mRNA as a novel target of the ubiquitous RNA-binding prot...

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Detalles Bibliográficos
Autores principales: Winkler, C, Doller, A, Imre, G, Badawi, A, Schmid, T, Schulz, S, Steinmeyer, N, Pfeilschifter, J, Rajalingam, K, Eberhardt, W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123073/
https://www.ncbi.nlm.nih.gov/pubmed/25010987
http://dx.doi.org/10.1038/cddis.2014.279

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