Usp9x- and Noxa-mediated Mcl-1 downregulation contributes to pemetrexed-induced apoptosis in human non-small-cell lung cancer cells

Pemetrexed, a folate antimetabolite, combined with cisplatin is used as a first-line therapy for malignant pleural mesothelioma (MPM) and locally advanced or metastatic non-small-cell lung cancer (NSCLC). Pemetrexed arrests cell cycle by inhibiting three enzymes in purine and pyrimidine synthesis th...

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Detalles Bibliográficos
Autores principales: Yan, J, Zhong, N, Liu, G, Chen, K, Liu, X, Su, L, Singhal, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123075/
https://www.ncbi.nlm.nih.gov/pubmed/24991768
http://dx.doi.org/10.1038/cddis.2014.281

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123075/
https://www.ncbi.nlm.nih.gov/pubmed/24991768
http://dx.doi.org/10.1038/cddis.2014.281

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