TGF-β/Smad3 inhibit vascular smooth muscle cell apoptosis through an autocrine signaling mechanism involving VEGF-A

We have previously shown that in the presence of elevated Smad3, transforming growth factor-β (TGF-β) transforms from an inhibitor to a stimulant of vascular smooth muscle cell (SMC) proliferation and intimal hyperplasia (IH). Here we identify a novel mechanism through which TGF-β/Smad3 also exacerb...

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Detalles Bibliográficos
Autores principales: Shi, X, Guo, L-W, Seedial, S M, Si, Y, Wang, B, Takayama, T, Suwanabol, P A, Ghosh, S, DiRenzo, D, Liu, B, Kent, K C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123076/
https://www.ncbi.nlm.nih.gov/pubmed/25010983
http://dx.doi.org/10.1038/cddis.2014.282

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