Integrative epigenome analysis identifies a Polycomb-targeted differentiation program as a tumor-suppressor event epigenetically inactivated in colorectal cancer

Aberrant DNA hypermethylation in human cancer has been associated with Polycomb target genes in embryonic stem (ES) cells, but a functional link of the Polycomb-targeted differentiation program to tumorigenesis remains to be established. Here, through epigenome analysis correlating DNA hypermethylat...

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Detalles Bibliográficos
Autores principales: Tan, J, Yang, X, Jiang, X, Zhou, J, Li, Z, Lee, P L, Li, B, Robson, P, Yu, Q
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123077/
https://www.ncbi.nlm.nih.gov/pubmed/25032847
http://dx.doi.org/10.1038/cddis.2014.283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123077/
https://www.ncbi.nlm.nih.gov/pubmed/25032847
http://dx.doi.org/10.1038/cddis.2014.283

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