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RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38
Significant advances have been made in the development of small molecules blocking the p53/MDM2 interaction. The Mdm2 inhibitor Nutlin-3 is restricted to tumors carrying wtp53. In contrast, RITA, a compound that binds p53, has recently been shown also to restore transcriptional functions of mtp53. A...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123078/ https://www.ncbi.nlm.nih.gov/pubmed/25010984 http://dx.doi.org/10.1038/cddis.2014.284 |