Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17

Transforming growth factor-beta (TGF-β) plays a dual role in hepatocytes, inducing both pro- and anti-apoptotic responses, whose balance decides cell fate. Survival signals are mediated by the epidermal growth factor receptor (EGFR) pathway, which is activated by TGF-β in these cells. Caveolin-1 (Ca...

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Detalles Bibliográficos
Autores principales: Moreno-Càceres, J, Caja, L, Mainez, J, Mayoral, R, Martín-Sanz, P, Moreno-Vicente, R, del Pozo, M Á, Dooley, S, Egea, G, Fabregat, I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123087/
https://www.ncbi.nlm.nih.gov/pubmed/25032849
http://dx.doi.org/10.1038/cddis.2014.294

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