miR-17 extends mouse lifespan by inhibiting senescence signaling mediated by MKP7

Here we show that transgenic expression of miR-17 extends lifespan and inhibits cellular senescence. We propose that miR-17 acts as a critical regulator of cellular senescence and tumorigenesis. We demonstrate that miR-17 targets both ADCY5 and IRS1, upregulating the downstream signals MKP7, FoxO3,...

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Detalles Bibliográficos
Autores principales: Du, W W, Yang, W, Fang, L, Xuan, J, Li, H, Khorshidi, A, Gupta, S, Li, X, Yang, B B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123096/
https://www.ncbi.nlm.nih.gov/pubmed/25077541
http://dx.doi.org/10.1038/cddis.2014.305

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