DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease

Parkinson's disease (PD) is a devastating neurodegenerative disorder characterized by the loss of neurons in the substantia nigra pars compacta and the presence of Lewy bodies in surviving neurons. These intracellular protein inclusions are primarily composed of misfolded α-synuclein (aSyn), wh...

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Detalles Bibliográficos
Autores principales: Zondler, L, Miller-Fleming, L, Repici, M, Gonçalves, S, Tenreiro, S, Rosado-Ramos, R, Betzer, C, Straatman, K R, Jensen, P H, Giorgini, F, Outeiro, T F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123098/
https://www.ncbi.nlm.nih.gov/pubmed/25058424
http://dx.doi.org/10.1038/cddis.2014.307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123098/
https://www.ncbi.nlm.nih.gov/pubmed/25058424
http://dx.doi.org/10.1038/cddis.2014.307

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