Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency

Loss of ataxia telangiectasia mutated (ATM) kinase, a key factor of the DNA damage response (DDR) pathway, causes the cancer predisposing and neurodegenerative syndrome ataxia-telangiectasia (A-T). To investigate the mechanisms of neurodegeneration, we have reprogrammed fibroblasts from ATM-null A-T...

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Detalles Bibliográficos
Autores principales: Carlessi, L, Poli, E Fusar, Bechi, G, Mantegazza, M, Pascucci, B, Narciso, L, Dogliotti, E, Sala, C, Verpelli, C, Lecis, D, Delia, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123100/
https://www.ncbi.nlm.nih.gov/pubmed/25032865
http://dx.doi.org/10.1038/cddis.2014.310

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