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Immortalised breast epithelia survive prolonged DNA replication stress and return to cycle from a senescent-like state
Mammalian cells have mechanisms to counteract the effects of metabolic and exogenous stresses, many of that would be mutagenic if ignored. Damage arising during DNA replication is a major source of mutagenesis. The extent of damage dictates whether cells undergo transient cell cycle arrest and damag...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123104/ https://www.ncbi.nlm.nih.gov/pubmed/25058425 http://dx.doi.org/10.1038/cddis.2014.315 |