Cargando…

Effect of pectin, lecithin, and antacid feed supplements (Egusin(®)) on gastric ulcer scores, gastric fluid pH and blood gas values in horses

BACKGROUND: The objectives of this study were to evaluate the effects of two commercial feed supplements, Egusin 250(®) [E-250] and Egusin SLH(®) [E-SLH], on gastric ulcer scores, gastric fluid pH, and blood gas values in stall-confined horses undergoing feed-deprivation. METHODS: Nine Thoroughbred...

Descripción completa

Detalles Bibliográficos
Autores principales: Woodward, Michelle C, Huff, Nan K, Garza, Frank, Keowen, Michael L, Kearney, Michael T, Andrews, Frank M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123152/
https://www.ncbi.nlm.nih.gov/pubmed/25238454
http://dx.doi.org/10.1186/1746-6148-10-S1-S4
_version_ 1782329465057050624
author Woodward, Michelle C
Huff, Nan K
Garza, Frank
Keowen, Michael L
Kearney, Michael T
Andrews, Frank M
author_facet Woodward, Michelle C
Huff, Nan K
Garza, Frank
Keowen, Michael L
Kearney, Michael T
Andrews, Frank M
author_sort Woodward, Michelle C
collection PubMed
description BACKGROUND: The objectives of this study were to evaluate the effects of two commercial feed supplements, Egusin 250(®) [E-250] and Egusin SLH(®) [E-SLH], on gastric ulcer scores, gastric fluid pH, and blood gas values in stall-confined horses undergoing feed-deprivation. METHODS: Nine Thoroughbred horses were used in a three-period crossover study. For the three treatment groups, sweet feed was mixed with E-250, E-SLH, or nothing (control group) and fed twice daily. Horses were treated for 21 days, then an additional 7 days while on an alternating feed-deprivation model to induce or worsen ulcers (period one). In periods two and three, horses (n=6) were treated for an additional 7 days after feed-deprivation. Gastroscopies were performed on day -1 (n=9), day 21 (n=9), day 28 (n=9) and day 35 (n=6). Gastric juice pH was measured and gastric ulcer scores were assigned. Venous blood gas values were also measured. RESULTS: Gastric ulcers in control horses significantly decreased after 21 days, but there was no difference in ulcer scores when compared to the Egusin® treated horses. NG gastric ulcer scores significantly increased in E-250 and control horses on day 28 compared to day 21 as a result of intermittent feed-deprivation, but no treatment effect was observed. NG ulcer scores remained high in the control group but significantly decreased in the E-SLH- and E-250-treated horses by day 35. Gastric juice pH values were low and variable and no treatment effect was observed. Mean blood pCO(2) values were significantly increased two hours after feeding in treated horses compared to controls, whereas mean blood TCO(2) values increased in the 24 hour sample, but did not exceed 38 mmol/l. CONCLUSIONS: The feed-deprivation model increased NG gastric ulcer severity in the horses. However, by day 35, Egusin(®) treated horses had less severe NG gastric ulcers compared to untreated control horses. After 35 days, Egusin(®) products tested here ameliorate the severity of gastric ulcers in stall-confined horses after feed stress.
format Online
Article
Text
id pubmed-4123152
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-41231522014-08-11 Effect of pectin, lecithin, and antacid feed supplements (Egusin(®)) on gastric ulcer scores, gastric fluid pH and blood gas values in horses Woodward, Michelle C Huff, Nan K Garza, Frank Keowen, Michael L Kearney, Michael T Andrews, Frank M BMC Vet Res Research Article BACKGROUND: The objectives of this study were to evaluate the effects of two commercial feed supplements, Egusin 250(®) [E-250] and Egusin SLH(®) [E-SLH], on gastric ulcer scores, gastric fluid pH, and blood gas values in stall-confined horses undergoing feed-deprivation. METHODS: Nine Thoroughbred horses were used in a three-period crossover study. For the three treatment groups, sweet feed was mixed with E-250, E-SLH, or nothing (control group) and fed twice daily. Horses were treated for 21 days, then an additional 7 days while on an alternating feed-deprivation model to induce or worsen ulcers (period one). In periods two and three, horses (n=6) were treated for an additional 7 days after feed-deprivation. Gastroscopies were performed on day -1 (n=9), day 21 (n=9), day 28 (n=9) and day 35 (n=6). Gastric juice pH was measured and gastric ulcer scores were assigned. Venous blood gas values were also measured. RESULTS: Gastric ulcers in control horses significantly decreased after 21 days, but there was no difference in ulcer scores when compared to the Egusin® treated horses. NG gastric ulcer scores significantly increased in E-250 and control horses on day 28 compared to day 21 as a result of intermittent feed-deprivation, but no treatment effect was observed. NG ulcer scores remained high in the control group but significantly decreased in the E-SLH- and E-250-treated horses by day 35. Gastric juice pH values were low and variable and no treatment effect was observed. Mean blood pCO(2) values were significantly increased two hours after feeding in treated horses compared to controls, whereas mean blood TCO(2) values increased in the 24 hour sample, but did not exceed 38 mmol/l. CONCLUSIONS: The feed-deprivation model increased NG gastric ulcer severity in the horses. However, by day 35, Egusin(®) treated horses had less severe NG gastric ulcers compared to untreated control horses. After 35 days, Egusin(®) products tested here ameliorate the severity of gastric ulcers in stall-confined horses after feed stress. BioMed Central 2014-07-07 /pmc/articles/PMC4123152/ /pubmed/25238454 http://dx.doi.org/10.1186/1746-6148-10-S1-S4 Text en Copyright © 2014 Woodward et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Woodward, Michelle C
Huff, Nan K
Garza, Frank
Keowen, Michael L
Kearney, Michael T
Andrews, Frank M
Effect of pectin, lecithin, and antacid feed supplements (Egusin(®)) on gastric ulcer scores, gastric fluid pH and blood gas values in horses
title Effect of pectin, lecithin, and antacid feed supplements (Egusin(®)) on gastric ulcer scores, gastric fluid pH and blood gas values in horses
title_full Effect of pectin, lecithin, and antacid feed supplements (Egusin(®)) on gastric ulcer scores, gastric fluid pH and blood gas values in horses
title_fullStr Effect of pectin, lecithin, and antacid feed supplements (Egusin(®)) on gastric ulcer scores, gastric fluid pH and blood gas values in horses
title_full_unstemmed Effect of pectin, lecithin, and antacid feed supplements (Egusin(®)) on gastric ulcer scores, gastric fluid pH and blood gas values in horses
title_short Effect of pectin, lecithin, and antacid feed supplements (Egusin(®)) on gastric ulcer scores, gastric fluid pH and blood gas values in horses
title_sort effect of pectin, lecithin, and antacid feed supplements (egusin(®)) on gastric ulcer scores, gastric fluid ph and blood gas values in horses
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123152/
https://www.ncbi.nlm.nih.gov/pubmed/25238454
http://dx.doi.org/10.1186/1746-6148-10-S1-S4
work_keys_str_mv AT woodwardmichellec effectofpectinlecithinandantacidfeedsupplementsegusinongastriculcerscoresgastricfluidphandbloodgasvaluesinhorses
AT huffnank effectofpectinlecithinandantacidfeedsupplementsegusinongastriculcerscoresgastricfluidphandbloodgasvaluesinhorses
AT garzafrank effectofpectinlecithinandantacidfeedsupplementsegusinongastriculcerscoresgastricfluidphandbloodgasvaluesinhorses
AT keowenmichaell effectofpectinlecithinandantacidfeedsupplementsegusinongastriculcerscoresgastricfluidphandbloodgasvaluesinhorses
AT kearneymichaelt effectofpectinlecithinandantacidfeedsupplementsegusinongastriculcerscoresgastricfluidphandbloodgasvaluesinhorses
AT andrewsfrankm effectofpectinlecithinandantacidfeedsupplementsegusinongastriculcerscoresgastricfluidphandbloodgasvaluesinhorses