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The effect of colloid formulation on colloid osmotic pressure in horses with naturally occurring gastrointestinal disease

BACKGROUND: Naturally occurring gastrointestinal disease is an important cause of acute hypoproteinemia in adult horses and hydroxyethyl starch colloid fluid treatment is a component of supportive care in these cases to improve plasma volume and maintain colloid osmotic pressure (COP). The objective...

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Autores principales: Bellezzo, Fausto, Kuhnmuench, Timothy, Hackett, Eileen S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123155/
https://www.ncbi.nlm.nih.gov/pubmed/25237987
http://dx.doi.org/10.1186/1746-6148-10-S1-S8
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author Bellezzo, Fausto
Kuhnmuench, Timothy
Hackett, Eileen S
author_facet Bellezzo, Fausto
Kuhnmuench, Timothy
Hackett, Eileen S
author_sort Bellezzo, Fausto
collection PubMed
description BACKGROUND: Naturally occurring gastrointestinal disease is an important cause of acute hypoproteinemia in adult horses and hydroxyethyl starch colloid fluid treatment is a component of supportive care in these cases to improve plasma volume and maintain colloid osmotic pressure (COP). The objectives of the present study were to compare 2 formulations of high molecular weight hydroxyethyl starch and their relative effect on COP, acid-base status, and survival of horses with acute hypoproteinemia secondary to gastrointestinal disease. METHODS: Twenty adult horses, ≥ 1 year of age, were prospectively enrolled, with informed client consent, if they developed acute hypoproteinemia, defined as a plasma total protein <5.0 g/dL or albumin <2.2 g/dL during hospitalization while undergoing treatment for gastrointestinal disease. Horses were randomly assigned to receive a rapid infusion of either 6% hydroxyethyl starch in 0.9% saline or 6% hydroxyethyl starch in lactated ringers solution at a dose of 10ml/kg. Venous blood gas analysis, COP, and PCV were evaluated before and after colloid administration. RESULTS: For both groups, average COP prior to treatment was 11.0 mmHg (9.7 – 12.2 mmHg) and post colloid treatment was 13.2 mmHg (12.0 -14.7 mmHg) [Normal range 18 – 22 mmHg]. COP was significantly increased with colloid treatment (p<0.001) but this increase was not significantly different between treatment groups. Venous pH did not change significantly with treatment. Twelve horses survived to hospital discharge and survival did not differ significantly between treatment groups. CONCLUSIONS: Post-treatment COP improved approximately 20% regardless of the formulation used, however, values did not reach the normal range of COP observed in healthy horses. Acid-base parameters were not significantly impacted by either treatment. Further study is needed to determine how these two products compare with regards to other outcome measures. Evaluation of the relative effects of colloid formulation in horses with clinical disease is a future area of interest.
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spelling pubmed-41231552014-08-11 The effect of colloid formulation on colloid osmotic pressure in horses with naturally occurring gastrointestinal disease Bellezzo, Fausto Kuhnmuench, Timothy Hackett, Eileen S BMC Vet Res Research Article BACKGROUND: Naturally occurring gastrointestinal disease is an important cause of acute hypoproteinemia in adult horses and hydroxyethyl starch colloid fluid treatment is a component of supportive care in these cases to improve plasma volume and maintain colloid osmotic pressure (COP). The objectives of the present study were to compare 2 formulations of high molecular weight hydroxyethyl starch and their relative effect on COP, acid-base status, and survival of horses with acute hypoproteinemia secondary to gastrointestinal disease. METHODS: Twenty adult horses, ≥ 1 year of age, were prospectively enrolled, with informed client consent, if they developed acute hypoproteinemia, defined as a plasma total protein <5.0 g/dL or albumin <2.2 g/dL during hospitalization while undergoing treatment for gastrointestinal disease. Horses were randomly assigned to receive a rapid infusion of either 6% hydroxyethyl starch in 0.9% saline or 6% hydroxyethyl starch in lactated ringers solution at a dose of 10ml/kg. Venous blood gas analysis, COP, and PCV were evaluated before and after colloid administration. RESULTS: For both groups, average COP prior to treatment was 11.0 mmHg (9.7 – 12.2 mmHg) and post colloid treatment was 13.2 mmHg (12.0 -14.7 mmHg) [Normal range 18 – 22 mmHg]. COP was significantly increased with colloid treatment (p<0.001) but this increase was not significantly different between treatment groups. Venous pH did not change significantly with treatment. Twelve horses survived to hospital discharge and survival did not differ significantly between treatment groups. CONCLUSIONS: Post-treatment COP improved approximately 20% regardless of the formulation used, however, values did not reach the normal range of COP observed in healthy horses. Acid-base parameters were not significantly impacted by either treatment. Further study is needed to determine how these two products compare with regards to other outcome measures. Evaluation of the relative effects of colloid formulation in horses with clinical disease is a future area of interest. BioMed Central 2014-07-07 /pmc/articles/PMC4123155/ /pubmed/25237987 http://dx.doi.org/10.1186/1746-6148-10-S1-S8 Text en Copyright © 2014 Bellezzo et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Bellezzo, Fausto
Kuhnmuench, Timothy
Hackett, Eileen S
The effect of colloid formulation on colloid osmotic pressure in horses with naturally occurring gastrointestinal disease
title The effect of colloid formulation on colloid osmotic pressure in horses with naturally occurring gastrointestinal disease
title_full The effect of colloid formulation on colloid osmotic pressure in horses with naturally occurring gastrointestinal disease
title_fullStr The effect of colloid formulation on colloid osmotic pressure in horses with naturally occurring gastrointestinal disease
title_full_unstemmed The effect of colloid formulation on colloid osmotic pressure in horses with naturally occurring gastrointestinal disease
title_short The effect of colloid formulation on colloid osmotic pressure in horses with naturally occurring gastrointestinal disease
title_sort effect of colloid formulation on colloid osmotic pressure in horses with naturally occurring gastrointestinal disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123155/
https://www.ncbi.nlm.nih.gov/pubmed/25237987
http://dx.doi.org/10.1186/1746-6148-10-S1-S8
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