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Imparting biomolecules to a metal-organic framework material by controlled DNA tetrahedron encapsulation

Recently, the incorporation of biomolecules in Metal-organic frameworks (MOFs) attracts many attentions because of controlling the functions, properties and stability of trapped molecules. Although there are few reports on protein/MOFs composites and their applications, none of DNA/MOFs composite is...

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Autores principales: Jia, Yongmei, Wei, Benmei, Duan, Ruixue, Zhang, Ying, Wang, Boya, Hakeem, Abdul, Liu, Nannan, Ou, Xiaowen, Xu, Shaofang, Chen, Zhifei, Lou, Xiaoding, Xia, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123201/
https://www.ncbi.nlm.nih.gov/pubmed/25090047
http://dx.doi.org/10.1038/srep05929
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author Jia, Yongmei
Wei, Benmei
Duan, Ruixue
Zhang, Ying
Wang, Boya
Hakeem, Abdul
Liu, Nannan
Ou, Xiaowen
Xu, Shaofang
Chen, Zhifei
Lou, Xiaoding
Xia, Fan
author_facet Jia, Yongmei
Wei, Benmei
Duan, Ruixue
Zhang, Ying
Wang, Boya
Hakeem, Abdul
Liu, Nannan
Ou, Xiaowen
Xu, Shaofang
Chen, Zhifei
Lou, Xiaoding
Xia, Fan
author_sort Jia, Yongmei
collection PubMed
description Recently, the incorporation of biomolecules in Metal-organic frameworks (MOFs) attracts many attentions because of controlling the functions, properties and stability of trapped molecules. Although there are few reports on protein/MOFs composites and their applications, none of DNA/MOFs composite is reported, as far as we know. Here, we report a new composite material which is self-assembled from 3D DNA (guest) and pre-synthesized MOFs (host) by electrostatic interactions and hydrophilic interactions in a well-dispersed fashion. Its biophysical characterization is well analyzed by fluorescence spectroscopy, quartz crystal microbalance (QCM) and transmission electron microscopy (TEM). This new composite material keeps 3D DNA nanostructure more stable than only 3D DNA nanostructure in DI water at room temperature, and stores amounts of genetic information. It will make DNA as a guest for MOFs and MOFs become a new platform for the development of DNA nanotechnology.
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spelling pubmed-41232012014-08-14 Imparting biomolecules to a metal-organic framework material by controlled DNA tetrahedron encapsulation Jia, Yongmei Wei, Benmei Duan, Ruixue Zhang, Ying Wang, Boya Hakeem, Abdul Liu, Nannan Ou, Xiaowen Xu, Shaofang Chen, Zhifei Lou, Xiaoding Xia, Fan Sci Rep Article Recently, the incorporation of biomolecules in Metal-organic frameworks (MOFs) attracts many attentions because of controlling the functions, properties and stability of trapped molecules. Although there are few reports on protein/MOFs composites and their applications, none of DNA/MOFs composite is reported, as far as we know. Here, we report a new composite material which is self-assembled from 3D DNA (guest) and pre-synthesized MOFs (host) by electrostatic interactions and hydrophilic interactions in a well-dispersed fashion. Its biophysical characterization is well analyzed by fluorescence spectroscopy, quartz crystal microbalance (QCM) and transmission electron microscopy (TEM). This new composite material keeps 3D DNA nanostructure more stable than only 3D DNA nanostructure in DI water at room temperature, and stores amounts of genetic information. It will make DNA as a guest for MOFs and MOFs become a new platform for the development of DNA nanotechnology. Nature Publishing Group 2014-08-04 /pmc/articles/PMC4123201/ /pubmed/25090047 http://dx.doi.org/10.1038/srep05929 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Article
Jia, Yongmei
Wei, Benmei
Duan, Ruixue
Zhang, Ying
Wang, Boya
Hakeem, Abdul
Liu, Nannan
Ou, Xiaowen
Xu, Shaofang
Chen, Zhifei
Lou, Xiaoding
Xia, Fan
Imparting biomolecules to a metal-organic framework material by controlled DNA tetrahedron encapsulation
title Imparting biomolecules to a metal-organic framework material by controlled DNA tetrahedron encapsulation
title_full Imparting biomolecules to a metal-organic framework material by controlled DNA tetrahedron encapsulation
title_fullStr Imparting biomolecules to a metal-organic framework material by controlled DNA tetrahedron encapsulation
title_full_unstemmed Imparting biomolecules to a metal-organic framework material by controlled DNA tetrahedron encapsulation
title_short Imparting biomolecules to a metal-organic framework material by controlled DNA tetrahedron encapsulation
title_sort imparting biomolecules to a metal-organic framework material by controlled dna tetrahedron encapsulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123201/
https://www.ncbi.nlm.nih.gov/pubmed/25090047
http://dx.doi.org/10.1038/srep05929
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