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Quality of Life in Non-Infectious Uveitis Patients on Immunosuppressive Therapy
PURPOSE: To assess visual function and vision related quality of life in patients with non-infectious posterior or panuveitis treated with immunosuppressives. MATERIALS AND METHODS: Forty-three patients with non-inflammatory posterior or panuveitis were enrolled in this prospective study. All subjec...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123274/ https://www.ncbi.nlm.nih.gov/pubmed/25100906 http://dx.doi.org/10.4103/0974-9233.134675 |
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author | Kaleemunnisha, Sheik Sudharshan, S. Biswas, Jyotirmay |
author_facet | Kaleemunnisha, Sheik Sudharshan, S. Biswas, Jyotirmay |
author_sort | Kaleemunnisha, Sheik |
collection | PubMed |
description | PURPOSE: To assess visual function and vision related quality of life in patients with non-infectious posterior or panuveitis treated with immunosuppressives. MATERIALS AND METHODS: Forty-three patients with non-inflammatory posterior or panuveitis were enrolled in this prospective study. All subjects underwent a detailed interview, complete ophthalmic examination, quality of life assessment using National Eye Institute Visual Function Questionnaire (VFQ-25), visual function evaluation (visual acuity and visual field) at baseline and at a sixth month follow up visit. RESULTS: The mean NEI-VFQ 25 composite score of the subjects with posterior or panuveitis was 58.0 (±24.1). There was a statistically significant improvement (P = 0.004) in the composite score following treatment from 58.0 (±24.1) to 74.3 (±22.0) with effect size of 1.03. The psychological well-being and general health subscales showed significant improvement in the mean score following immunosuppressive therapy. While considering the visual function tests, there was a three-line improvement in the visual acuity score and changeover in the visual field severity from moderate to early defect with corresponding improvement in the visual field pattern. Though most of the patients complained of side effects such as tiredness, gastrointestinal upset and weight gain, there was improvement in the general health subscale. CONCLUSION: The significant improvement in the general health subscale despite side-effects shows that the benefit of immunosuppressive outweighs the risks of the therapy and this may also reflect the relatively low impact of these side-effects on the quality of life. This study shows that the use of immunosuppressives improves the quality of life of the individual. |
format | Online Article Text |
id | pubmed-4123274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41232742014-08-06 Quality of Life in Non-Infectious Uveitis Patients on Immunosuppressive Therapy Kaleemunnisha, Sheik Sudharshan, S. Biswas, Jyotirmay Middle East Afr J Ophthalmol Original Article PURPOSE: To assess visual function and vision related quality of life in patients with non-infectious posterior or panuveitis treated with immunosuppressives. MATERIALS AND METHODS: Forty-three patients with non-inflammatory posterior or panuveitis were enrolled in this prospective study. All subjects underwent a detailed interview, complete ophthalmic examination, quality of life assessment using National Eye Institute Visual Function Questionnaire (VFQ-25), visual function evaluation (visual acuity and visual field) at baseline and at a sixth month follow up visit. RESULTS: The mean NEI-VFQ 25 composite score of the subjects with posterior or panuveitis was 58.0 (±24.1). There was a statistically significant improvement (P = 0.004) in the composite score following treatment from 58.0 (±24.1) to 74.3 (±22.0) with effect size of 1.03. The psychological well-being and general health subscales showed significant improvement in the mean score following immunosuppressive therapy. While considering the visual function tests, there was a three-line improvement in the visual acuity score and changeover in the visual field severity from moderate to early defect with corresponding improvement in the visual field pattern. Though most of the patients complained of side effects such as tiredness, gastrointestinal upset and weight gain, there was improvement in the general health subscale. CONCLUSION: The significant improvement in the general health subscale despite side-effects shows that the benefit of immunosuppressive outweighs the risks of the therapy and this may also reflect the relatively low impact of these side-effects on the quality of life. This study shows that the use of immunosuppressives improves the quality of life of the individual. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4123274/ /pubmed/25100906 http://dx.doi.org/10.4103/0974-9233.134675 Text en Copyright: © Middle East African Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kaleemunnisha, Sheik Sudharshan, S. Biswas, Jyotirmay Quality of Life in Non-Infectious Uveitis Patients on Immunosuppressive Therapy |
title | Quality of Life in Non-Infectious Uveitis Patients on Immunosuppressive Therapy |
title_full | Quality of Life in Non-Infectious Uveitis Patients on Immunosuppressive Therapy |
title_fullStr | Quality of Life in Non-Infectious Uveitis Patients on Immunosuppressive Therapy |
title_full_unstemmed | Quality of Life in Non-Infectious Uveitis Patients on Immunosuppressive Therapy |
title_short | Quality of Life in Non-Infectious Uveitis Patients on Immunosuppressive Therapy |
title_sort | quality of life in non-infectious uveitis patients on immunosuppressive therapy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123274/ https://www.ncbi.nlm.nih.gov/pubmed/25100906 http://dx.doi.org/10.4103/0974-9233.134675 |
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