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RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy
WASH (Wiskott-Aldrich syndrome protein (WASP) and SCAR homolog) was identified to function in endosomal sorting via Arp2/3 activation. We previously demonstrated that WASH is a new interactor of BECN1 and present in the BECN1-PIK3C3 complex with AMBRA1. The AMBRA1-DDB1-CUL4A complex is an E3 ligase...
Autores principales: | Xia, Pengyan, Wang, Shuo, Huang, Guanling, Du, Ying, Zhu, Pingping, Li, Man, Fan, Zusen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123297/ https://www.ncbi.nlm.nih.gov/pubmed/24980959 http://dx.doi.org/10.1038/cr.2014.85 |
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