UVA-UVB Photoprotective Activity of Topical Formulations Containing Morinda citrifolia Extract

Exposure to solar radiation, particularly its ultraviolet (UV) component, has a variety of harmful effects on human health. Some of these effects include sunburn cell formations, basal and squamous cell cancers, melanoma, cataracts, photoaging of the skin, and immune suppression. The beneficial phot...

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Detalles Bibliográficos
Autores principales: Serafini, Mairim Russo, Detoni, Cassia Britto, Menezes, Paula dos Passos, Pereira Filho, Rose Nely, Fortes, Vanessa Silveira, Vieira, Maria José Fonseca, Guterres, Sílvia Stanisçuaski, de Albuquerque Junior, Ricardo Luiz Cavalcanti, Araújo, Adriano Antunes de Souza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123522/
https://www.ncbi.nlm.nih.gov/pubmed/25133171
http://dx.doi.org/10.1155/2014/587819
Descripción
Sumario:Exposure to solar radiation, particularly its ultraviolet (UV) component, has a variety of harmful effects on human health. Some of these effects include sunburn cell formations, basal and squamous cell cancers, melanoma, cataracts, photoaging of the skin, and immune suppression. The beneficial photoprotective effects of topical formulations with the extract, Morinda citrifolia, have not been investigated. This present study aims to investigate the potential benefits of M. citrifolia topical application on the dorsal skin of mice, exposed to UVA-UVB light. Using 7 days of treatment, [before (baseline values) and 20 h after UV exposure], the thickness, skin barrier damage (TEWL), erythema, and histological alterations were evaluated. The results showed that the formulations containing the extract protected the skin against UV-induced damage.

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