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Mixed housing with DBA/2 mice induces stress in C57BL/6 mice: implications for interventions based on social enrichment
Several behavioral interventions, based on social enrichment and observational learning are applied in treatment of neuropsychiatric disorders. However, the mechanism of such modulatory effect and the safety of applied methods on individuals involved in social support need further investigation. We...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123727/ https://www.ncbi.nlm.nih.gov/pubmed/25147512 http://dx.doi.org/10.3389/fnbeh.2014.00257 |
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author | Kulesskaya, Natalia Karpova, Nina N. Ma, Li Tian, Li Voikar, Vootele |
author_facet | Kulesskaya, Natalia Karpova, Nina N. Ma, Li Tian, Li Voikar, Vootele |
author_sort | Kulesskaya, Natalia |
collection | PubMed |
description | Several behavioral interventions, based on social enrichment and observational learning are applied in treatment of neuropsychiatric disorders. However, the mechanism of such modulatory effect and the safety of applied methods on individuals involved in social support need further investigation. We took advantage of known differences between inbred mouse strains to reveal the effect of social enrichment on behavior and neurobiology of animals with different behavioral phenotypes. C57BL/6 and DBA/2 female mice displaying multiple differences in cognitive, social, and emotional behavior were group-housed either in same-strain or in mixed-strain conditions. Comprehensive behavioral phenotyping and analysis of expression of several plasticity- and stress-related genes were done to measure the reciprocal effects of social interaction between the strains. Contrary to our expectation, mixed housing did not change the behavior of DBA/2 mice. Nevertheless, the level of serum corticosterone and the expression of glucocorticoid receptor Nr3c1 in the brain were increased in mixed housed DBA/2 as compared with those of separately housed DBA/2 mice. In contrast, socially active C57BL/6 animals were more sensitive to the mixed housing, displaying several signs of stress: alterations in learning, social, and anxiety-like behavior and anhedonia. These behavioral impairments were accompanied by the elevated serum corticosterone and the reduced expression of Nr3c1, as well as the elevated Bdnf levels in the cortex and hippocampus. Our results demonstrate the importance of social factors in modulation of both behavior and the underlying neurobiological mechanisms in stress response, and draw attention to the potential negative impact of social interventions for individuals involved in social support. |
format | Online Article Text |
id | pubmed-4123727 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-41237272014-08-21 Mixed housing with DBA/2 mice induces stress in C57BL/6 mice: implications for interventions based on social enrichment Kulesskaya, Natalia Karpova, Nina N. Ma, Li Tian, Li Voikar, Vootele Front Behav Neurosci Neuroscience Several behavioral interventions, based on social enrichment and observational learning are applied in treatment of neuropsychiatric disorders. However, the mechanism of such modulatory effect and the safety of applied methods on individuals involved in social support need further investigation. We took advantage of known differences between inbred mouse strains to reveal the effect of social enrichment on behavior and neurobiology of animals with different behavioral phenotypes. C57BL/6 and DBA/2 female mice displaying multiple differences in cognitive, social, and emotional behavior were group-housed either in same-strain or in mixed-strain conditions. Comprehensive behavioral phenotyping and analysis of expression of several plasticity- and stress-related genes were done to measure the reciprocal effects of social interaction between the strains. Contrary to our expectation, mixed housing did not change the behavior of DBA/2 mice. Nevertheless, the level of serum corticosterone and the expression of glucocorticoid receptor Nr3c1 in the brain were increased in mixed housed DBA/2 as compared with those of separately housed DBA/2 mice. In contrast, socially active C57BL/6 animals were more sensitive to the mixed housing, displaying several signs of stress: alterations in learning, social, and anxiety-like behavior and anhedonia. These behavioral impairments were accompanied by the elevated serum corticosterone and the reduced expression of Nr3c1, as well as the elevated Bdnf levels in the cortex and hippocampus. Our results demonstrate the importance of social factors in modulation of both behavior and the underlying neurobiological mechanisms in stress response, and draw attention to the potential negative impact of social interventions for individuals involved in social support. Frontiers Media S.A. 2014-08-06 /pmc/articles/PMC4123727/ /pubmed/25147512 http://dx.doi.org/10.3389/fnbeh.2014.00257 Text en Copyright © 2014 Kulesskaya, Karpova, Ma, Tian and Voikar. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Kulesskaya, Natalia Karpova, Nina N. Ma, Li Tian, Li Voikar, Vootele Mixed housing with DBA/2 mice induces stress in C57BL/6 mice: implications for interventions based on social enrichment |
title | Mixed housing with DBA/2 mice induces stress in C57BL/6 mice: implications for interventions based on social enrichment |
title_full | Mixed housing with DBA/2 mice induces stress in C57BL/6 mice: implications for interventions based on social enrichment |
title_fullStr | Mixed housing with DBA/2 mice induces stress in C57BL/6 mice: implications for interventions based on social enrichment |
title_full_unstemmed | Mixed housing with DBA/2 mice induces stress in C57BL/6 mice: implications for interventions based on social enrichment |
title_short | Mixed housing with DBA/2 mice induces stress in C57BL/6 mice: implications for interventions based on social enrichment |
title_sort | mixed housing with dba/2 mice induces stress in c57bl/6 mice: implications for interventions based on social enrichment |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123727/ https://www.ncbi.nlm.nih.gov/pubmed/25147512 http://dx.doi.org/10.3389/fnbeh.2014.00257 |
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