The PYRIN domain-only protein POP3 inhibits AIM2-like receptor inflammasomes and regulates responses to DNA virus infections

The innate immune system responds to infections and tissue damage by activating cytosolic sensory complexes called inflammasomes. Cytosolic DNA is sensed by AIM2-like receptors (ALRs) during bacterial and viral infections and in autoimmune diseases. Subsequently, recruitment of the adaptor protein A...

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Detalles Bibliográficos
Autores principales: Khare, Sonal, Ratsimandresy, Rojo A., de Almeida, Lúcia, Cuda, Carla M., Rellick, Stephanie L., Misharin, Alexander V., Wallin, Melissa C., Gangopadhyay, Anu, Forte, Eleonora, Gottwein, Eva, Perlman, Harris, Reed, John C., Greaves, David R., Dorfleutner, Andrea, Stehlik, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123781/
https://www.ncbi.nlm.nih.gov/pubmed/24531343
http://dx.doi.org/10.1038/ni.2829

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