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Circulating TNF Receptors Are Significant Prognostic Biomarkers for Idiopathic Membranous Nephropathy
Idiopathic membranous nephropathy (iMN) is a common cause of nephrotic syndrome in adults. A biomarker to accurately indicate the severity of iMN and predict long-term prognosis is insufficient. Here, we evaluated the clinical significance of circulating tumor necrosis factor receptors (cTNFRs) as p...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123977/ https://www.ncbi.nlm.nih.gov/pubmed/25098821 http://dx.doi.org/10.1371/journal.pone.0104354 |
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author | Lee, Su Mi Yang, SeungHee Cha, Ran-hui Kim, Myounghee An, Jung Nam Paik, Jin Ho Kim, Dong Ki Kang, Shin-Wook Lim, Chun Soo Kim, Yon Su Lee, Jung Pyo |
author_facet | Lee, Su Mi Yang, SeungHee Cha, Ran-hui Kim, Myounghee An, Jung Nam Paik, Jin Ho Kim, Dong Ki Kang, Shin-Wook Lim, Chun Soo Kim, Yon Su Lee, Jung Pyo |
author_sort | Lee, Su Mi |
collection | PubMed |
description | Idiopathic membranous nephropathy (iMN) is a common cause of nephrotic syndrome in adults. A biomarker to accurately indicate the severity of iMN and predict long-term prognosis is insufficient. Here, we evaluated the clinical significance of circulating tumor necrosis factor receptors (cTNFRs) as prognostic biomarkers of iMN with nephrotic syndrome. A total of 113 patients with biopsy-proven iMN and 43 healthy volunteers were enrolled in this study. Ninety patients with iMN had nephrotic range proteinuria. Levels of cTNFRs were measured by using serum samples collected at the time of initial diagnosis. Levels of cTNFRs were higher in the patients with nephrotic syndrome than in those with subnephrotic range proteinuria or in the healthy volunteers (P for trend <0.001). Estimated glomerular filtration rate and proteinuria tended to worsen as the cTNFRs levels increased. Having a cTNFR1 level within the highest tertile was a significant risk factor for renal progression after adjustment, in comparison with the other tertiles (hazard ratio [HR], 3.39; 95% confidence interval [95% CI], 1.48–7.78; P = 0.004). The cTNFR2 level within the highest tertile also significantly increased the risk of renal progression (HR, 3.29; 95% CI, 1.43–7.54; P = 0.005). Renal tubular TNFRs expression was associated with cTNFRs level. However, the cTNFRs levels were not associated with autoantibody against phospholipase A(2) receptor reactivity/levels or treatment response. This study demonstrated that cTNFRs levels at the time of initial diagnosis could predict renal progression in patients with iMN. |
format | Online Article Text |
id | pubmed-4123977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-41239772014-08-12 Circulating TNF Receptors Are Significant Prognostic Biomarkers for Idiopathic Membranous Nephropathy Lee, Su Mi Yang, SeungHee Cha, Ran-hui Kim, Myounghee An, Jung Nam Paik, Jin Ho Kim, Dong Ki Kang, Shin-Wook Lim, Chun Soo Kim, Yon Su Lee, Jung Pyo PLoS One Research Article Idiopathic membranous nephropathy (iMN) is a common cause of nephrotic syndrome in adults. A biomarker to accurately indicate the severity of iMN and predict long-term prognosis is insufficient. Here, we evaluated the clinical significance of circulating tumor necrosis factor receptors (cTNFRs) as prognostic biomarkers of iMN with nephrotic syndrome. A total of 113 patients with biopsy-proven iMN and 43 healthy volunteers were enrolled in this study. Ninety patients with iMN had nephrotic range proteinuria. Levels of cTNFRs were measured by using serum samples collected at the time of initial diagnosis. Levels of cTNFRs were higher in the patients with nephrotic syndrome than in those with subnephrotic range proteinuria or in the healthy volunteers (P for trend <0.001). Estimated glomerular filtration rate and proteinuria tended to worsen as the cTNFRs levels increased. Having a cTNFR1 level within the highest tertile was a significant risk factor for renal progression after adjustment, in comparison with the other tertiles (hazard ratio [HR], 3.39; 95% confidence interval [95% CI], 1.48–7.78; P = 0.004). The cTNFR2 level within the highest tertile also significantly increased the risk of renal progression (HR, 3.29; 95% CI, 1.43–7.54; P = 0.005). Renal tubular TNFRs expression was associated with cTNFRs level. However, the cTNFRs levels were not associated with autoantibody against phospholipase A(2) receptor reactivity/levels or treatment response. This study demonstrated that cTNFRs levels at the time of initial diagnosis could predict renal progression in patients with iMN. Public Library of Science 2014-08-06 /pmc/articles/PMC4123977/ /pubmed/25098821 http://dx.doi.org/10.1371/journal.pone.0104354 Text en © 2014 Lee et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Lee, Su Mi Yang, SeungHee Cha, Ran-hui Kim, Myounghee An, Jung Nam Paik, Jin Ho Kim, Dong Ki Kang, Shin-Wook Lim, Chun Soo Kim, Yon Su Lee, Jung Pyo Circulating TNF Receptors Are Significant Prognostic Biomarkers for Idiopathic Membranous Nephropathy |
title | Circulating TNF Receptors Are Significant Prognostic Biomarkers for Idiopathic Membranous Nephropathy |
title_full | Circulating TNF Receptors Are Significant Prognostic Biomarkers for Idiopathic Membranous Nephropathy |
title_fullStr | Circulating TNF Receptors Are Significant Prognostic Biomarkers for Idiopathic Membranous Nephropathy |
title_full_unstemmed | Circulating TNF Receptors Are Significant Prognostic Biomarkers for Idiopathic Membranous Nephropathy |
title_short | Circulating TNF Receptors Are Significant Prognostic Biomarkers for Idiopathic Membranous Nephropathy |
title_sort | circulating tnf receptors are significant prognostic biomarkers for idiopathic membranous nephropathy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123977/ https://www.ncbi.nlm.nih.gov/pubmed/25098821 http://dx.doi.org/10.1371/journal.pone.0104354 |
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