Cargando…

The stem cell adjuvant with Exendin-4 repairs the heart after myocardial infarction via STAT3 activation

The poor survival of cells in ischaemic myocardium is a major obstacle for stem cell therapy. Exendin-4 holds the potential of cardioprotective effect based on its pleiotropic activity. This study investigated whether Exendin-4 in conjunction with adipose-derived stem cells (ADSCs) could improve the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Jianfeng, Wang, Haibin, Wang, Yan, Yin, Yujing, Du, Zhiyan, Liu, Zhiqiang, Yang, Junjie, Hu, Shunying, Wang, Changyong, Chen, Yundai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2014
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124022/ https://www.ncbi.nlm.nih.gov/pubmed/24779911 http://dx.doi.org/10.1111/jcmm.12272

Ejemplares similares

Exendin-4 Pretreated Adipose Derived Stem Cells Are Resistant to Oxidative Stress and Improve Cardiac Performance via Enhanced Adhesion in the Infarcted Heart
por: Liu, Jianfeng, et al.
Publicado: (2014)

Injectable cardiac tissue engineering for the treatment of myocardial infarction
por: Wang, Haibin, et al.
Publicado: (2010)

Effects of Exendin-4 on bone marrow mesenchymal stem cell proliferation, migration and apoptosis in vitro
por: Zhou, Hao, et al.
Publicado: (2015)

Injectable biodegradable hydrogels for embryonic stem cell transplantation: improved cardiac remodelling and function of myocardial infarction
por: Wang, Haibin, et al.
Publicado: (2012)

Engineered heart tissue graft derived from somatic cell nuclear transferred embryonic stem cells improve myocardial performance in infarcted rat heart
por: Lü, Shuanghong, et al.
Publicado: (2010)

Diagnostic and treatment value of XPNPEP3 in acute myocardial infarction
por: Ai, Lunna, et al.
Publicado: (2023)

Exendin-4 inhibits atrial arrhythmogenesis in a model of myocardial infarction-induced heart failure via the GLP-1 receptor signaling pathway
por: Chen, Jingjing, et al.
Publicado: (2020)

Transferrin improved the generation of cardiomyocyte from human pluripotent stem cells for myocardial infarction repair
por: Zhang, Fengzhi, et al.
Publicado: (2020)

Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission
por: Zhou, Hao, et al.
Publicado: (2017)

Exendin-4 protects against post-myocardial infarction remodelling via specific actions on inflammation and the extracellular matrix
por: Robinson, Emma, et al.
Publicado: (2015)

Molecular Imaging of Induced Pluripotent Stem Cell Immunogenicity with In Vivo Development in Ischemic Myocardium
por: Liu, Zhiqiang, et al.
Publicado: (2013)

Melatonin protects ADSCs from ROS and enhances their therapeutic potency in a rat model of myocardial infarction
por: Zhu, Ping, et al.
Publicado: (2015)

Nephronectin promotes cardiac repair post myocardial infarction via activating EGFR/JAK2/STAT3 pathway
por: Zhang, Yaping, et al.
Publicado: (2022)

Cardioprotective Role of Melatonin in Acute Myocardial Infarction
por: Fu, Zhenhong, et al.
Publicado: (2020)

The tumourigenicity of iPS cells and their differentiated derivates
por: Liu, Zhiqiang, et al.
Publicado: (2013)

The Role of Hydrogel in Cardiac Repair and Regeneration for Myocardial Infarction: Recent Advances and Future Perspectives
por: Li, Ping, et al.
Publicado: (2023)

Myocardial infarction following repair of a ruptured heart
por: Vakili, Hossein, et al.
Publicado: (2021)

Exendin-4 for Parkinson's disease
por: Esparza-Salazar, Felipe de Jesús, et al.
Publicado: (2021)

STAT1 deficiency in the heart protects against myocardial infarction by enhancing autophagy
por: McCormick, J, et al.
Publicado: (2012)

Clinical characteristics and prognosis of acute myocardial infarction in young smokers and non-smokers (≤ 45 years): a systematic review and meta-analysis
por: Liu, Yuqi, et al.
Publicado: (2017)

Preliminary evaluation of (18)F-AlF-NOTA-MAL-Cys(40)-Exendin-4 in rodent heart after myocardial ischemia and reperfusion
por: Pan, Xietian, et al.
Publicado: (2019)

Current status of induced pluripotent stem cells in cardiac tissue regeneration and engineering
por: Liu, Zhiqiang, et al.
Publicado: (2013)

An IL-6/STAT3/MR/FGF21 axis mediates heart-liver cross-talk after myocardial infarction
por: Sun, Jian-Yong, et al.
Publicado: (2023)

Inhibition of Oct 3/4 mitigates the cardiac progenitor-derived myocardial repair in infarcted myocardium
por: Zhao, Yu Tina, et al.
Publicado: (2015)

In Vitro Metabolic Stability of Exendin-4: Pharmacokinetics and Identification of Cleavage Products
por: Liao, Sha, et al.
Publicado: (2015)

Exendin-4 enhances the migration of adipose-derived stem cells to neonatal rat ventricular cardiomyocyte-derived conditioned medium via the phosphoinositide 3-kinase/Akt-stromal cell-derived factor-1α/CXC chemokine receptor 4 pathway
por: ZHOU, HAO, et al.
Publicado: (2015)

ER–Mitochondria Microdomains in Cardiac Ischemia–Reperfusion Injury: A Fresh Perspective
por: Zhou, Hao, et al.
Publicado: (2018)

Exendin‐4 analogs in insulinoma theranostics
por: Jansen, Tom.J.P., et al.
Publicado: (2019)

Exendin-4 promotes osteogenic differentiation of adipose-derived stem cells and facilitates bone repair
por: Deng, Banglian, et al.
Publicado: (2019)

Glucagon-like peptide-1 receptor expression after myocardial infarction: Imaging study using (68)Ga-NODAGA-exendin-4 positron emission tomography
por: Ståhle, Mia, et al.
Publicado: (2018)

Repair mechanisms of bone marrow mesenchymal stem cells in myocardial infarction
por: Wen, Zhuzhi, et al.
Publicado: (2011)

(Re) Solving Repair After Myocardial Infarction
por: Leoni, Giovanna, et al.
Publicado: (2018)

Melatonin Engineered Adipose-Derived Biomimetic Nanovesicles Regulate Mitochondrial Functions and Promote Myocardial Repair in Myocardial Infarction
por: Zhang, Yang, et al.
Publicado: (2022)

Exendin-4 enhances expression of Neurod1 and Glut2 in insulin-producing cells derived from mouse embryonic stem cells
por: Zhao, Qiaoshi, et al.
Publicado: (2016)

Human heart valve-derived scaffold improves cardiac repair in a murine model of myocardial infarction
por: Wan, Long, et al.
Publicado: (2017)

High concentrations of H7 human embryonic stem cells at the point of care for acute myocardial infarction
por: Shi, Yujie, et al.
Publicado: (2020)

Percutaneous Intramyocardial Delivery of Mesenchymal Stem Cells Induces Superior Improvement in Regional Left Ventricular Function Compared with Bone Marrow Mononuclear Cells in Porcine Myocardial Infarcted Heart
por: Tao, Bo, et al.
Publicado: (2015)

The Inflammatory Response and Cardiac Repair After Myocardial Infarction
por: Nah, Deuk-Young, et al.
Publicado: (2009)

Exendin-4 Attenuates Hepatic Steatosis by Promoting the Autophagy-Lysosomal Pathway
por: Yu, Hsin-Hsien, et al.
Publicado: (2022)

JNK3 Is Required for the Cytoprotective Effect of Exendin 4
por: Ezanno, Hélène, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_1f298op7b2n70ph4g3umqb1cs9