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Effects of JAK2-STAT3 signaling after cerebral insults
The JAK2-STAT3 signaling pathway has been shown to regulate the expression of genes involved in cell survival, cell proliferation, cell-cycle progression, and angiogenesis in development and after cerebral insults. Until recently, little has been known about the effects of this pathway activation af...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124058/ https://www.ncbi.nlm.nih.gov/pubmed/25105066 http://dx.doi.org/10.4161/jkst.29510 |
| _version_ | 1782329576901312512 |
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| author | Raible, Daniel J Frey, Lauren C Brooks-Kayal, Amy R |
| author_facet | Raible, Daniel J Frey, Lauren C Brooks-Kayal, Amy R |
| author_sort | Raible, Daniel J |
| collection | PubMed |
| description | The JAK2-STAT3 signaling pathway has been shown to regulate the expression of genes involved in cell survival, cell proliferation, cell-cycle progression, and angiogenesis in development and after cerebral insults. Until recently, little has been known about the effects of this pathway activation after cerebral insults and if blocking this pathway leads to better recovery. This review exams the role of this pathway after 3 cerebral insults (traumatic brain injury, stroke, and status epilepticus). |
| format | Online Article Text |
| id | pubmed-4124058 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | Landes Bioscience |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-41240582014-08-07 Effects of JAK2-STAT3 signaling after cerebral insults Raible, Daniel J Frey, Lauren C Brooks-Kayal, Amy R JAKSTAT Review The JAK2-STAT3 signaling pathway has been shown to regulate the expression of genes involved in cell survival, cell proliferation, cell-cycle progression, and angiogenesis in development and after cerebral insults. Until recently, little has been known about the effects of this pathway activation after cerebral insults and if blocking this pathway leads to better recovery. This review exams the role of this pathway after 3 cerebral insults (traumatic brain injury, stroke, and status epilepticus). Landes Bioscience 2014-06-12 /pmc/articles/PMC4124058/ /pubmed/25105066 http://dx.doi.org/10.4161/jkst.29510 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| spellingShingle | Review Raible, Daniel J Frey, Lauren C Brooks-Kayal, Amy R Effects of JAK2-STAT3 signaling after cerebral insults |
| title | Effects of JAK2-STAT3 signaling after cerebral insults |
| title_full | Effects of JAK2-STAT3 signaling after cerebral insults |
| title_fullStr | Effects of JAK2-STAT3 signaling after cerebral insults |
| title_full_unstemmed | Effects of JAK2-STAT3 signaling after cerebral insults |
| title_short | Effects of JAK2-STAT3 signaling after cerebral insults |
| title_sort | effects of jak2-stat3 signaling after cerebral insults |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124058/ https://www.ncbi.nlm.nih.gov/pubmed/25105066 http://dx.doi.org/10.4161/jkst.29510 |
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