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2′-(2-bromohexadecanoyl)-paclitaxel conjugate nanoparticles for the treatment of non-small cell lung cancer in an orthotopic xenograft mouse model

A nanoparticle (NP) formulation with 2′-(2-bromohexadecanoyl)-paclitaxel (Br-16-PX) conjugate was developed in these studies for the treatment of non-small cell lung cancer (NSCLC). The lipophilic paclitaxel conjugate Br-C16-PX was synthesized and incorporated into lipid NPs where the 16-carbon chai...

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Detalles Bibliográficos
Autores principales:	Peng, Lei, Schorzman, Allison N, Ma, Ping, Madden, Andrew J, Zamboni, William C, Benhabbour, Soumya Rahima, Mumper, Russell J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2014
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124067/ https://www.ncbi.nlm.nih.gov/pubmed/25114529 http://dx.doi.org/10.2147/IJN.S66040

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