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Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases

Alpha-lipoic acid is a naturally occurring substance, essential for the function of different enzymes that take part in mitochondria’s oxidative metabolism. It is believed that alpha-lipoic acid or its reduced form, dihydrolipoic acid have many biochemical functions acting as biological antioxidants...

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Autores principales: Gomes, Marilia Brito, Negrato, Carlos Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124142/
https://www.ncbi.nlm.nih.gov/pubmed/25104975
http://dx.doi.org/10.1186/1758-5996-6-80
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author Gomes, Marilia Brito
Negrato, Carlos Antonio
author_facet Gomes, Marilia Brito
Negrato, Carlos Antonio
author_sort Gomes, Marilia Brito
collection PubMed
description Alpha-lipoic acid is a naturally occurring substance, essential for the function of different enzymes that take part in mitochondria’s oxidative metabolism. It is believed that alpha-lipoic acid or its reduced form, dihydrolipoic acid have many biochemical functions acting as biological antioxidants, as metal chelators, reducers of the oxidized forms of other antioxidant agents such as vitamin C and E, and modulator of the signaling transduction of several pathways. These above-mentioned actions have been shown in experimental studies emphasizing the use of alpha-lipoic acid as a potential therapeutic agent for many chronic diseases with great epidemiological as well economic and social impact such as brain diseases and cognitive dysfunctions like Alzheimer disease, obesity, nonalcoholic fatty liver disease, burning mouth syndrome, cardiovascular disease, hypertension, some types of cancer, glaucoma and osteoporosis. Many conflicting data have been found concerning the clinical use of alpha-lipoic acid in the treatment of diabetes and of diabetes-related chronic complications such as retinopathy, nephropathy, neuropathy, wound healing and diabetic cardiovascular autonomic neuropathy. The most frequent clinical condition in which alpha-lipoic acid has been studied was in the management of diabetic peripheral neuropathy in patients with type 1 as well type 2 diabetes. Considering that oxidative stress, a imbalance between pro and antioxidants with excessive production of reactive oxygen species, is a factor in the development of many diseases and that alpha-lipoic acid, a natural thiol antioxidant, has been shown to have beneficial effects on oxidative stress parameters in various tissues we wrote this article in order to make an up-to-date review of current thinking regarding alpha-lipoic acid and its use as an antioxidant drug therapy for a myriad of diseases that could have potential benefits from its use. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1758-5996-6-80) contains supplementary material, which is available to authorized users.
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spelling pubmed-41241422014-08-08 Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases Gomes, Marilia Brito Negrato, Carlos Antonio Diabetol Metab Syndr Research Alpha-lipoic acid is a naturally occurring substance, essential for the function of different enzymes that take part in mitochondria’s oxidative metabolism. It is believed that alpha-lipoic acid or its reduced form, dihydrolipoic acid have many biochemical functions acting as biological antioxidants, as metal chelators, reducers of the oxidized forms of other antioxidant agents such as vitamin C and E, and modulator of the signaling transduction of several pathways. These above-mentioned actions have been shown in experimental studies emphasizing the use of alpha-lipoic acid as a potential therapeutic agent for many chronic diseases with great epidemiological as well economic and social impact such as brain diseases and cognitive dysfunctions like Alzheimer disease, obesity, nonalcoholic fatty liver disease, burning mouth syndrome, cardiovascular disease, hypertension, some types of cancer, glaucoma and osteoporosis. Many conflicting data have been found concerning the clinical use of alpha-lipoic acid in the treatment of diabetes and of diabetes-related chronic complications such as retinopathy, nephropathy, neuropathy, wound healing and diabetic cardiovascular autonomic neuropathy. The most frequent clinical condition in which alpha-lipoic acid has been studied was in the management of diabetic peripheral neuropathy in patients with type 1 as well type 2 diabetes. Considering that oxidative stress, a imbalance between pro and antioxidants with excessive production of reactive oxygen species, is a factor in the development of many diseases and that alpha-lipoic acid, a natural thiol antioxidant, has been shown to have beneficial effects on oxidative stress parameters in various tissues we wrote this article in order to make an up-to-date review of current thinking regarding alpha-lipoic acid and its use as an antioxidant drug therapy for a myriad of diseases that could have potential benefits from its use. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1758-5996-6-80) contains supplementary material, which is available to authorized users. BioMed Central 2014-07-28 /pmc/articles/PMC4124142/ /pubmed/25104975 http://dx.doi.org/10.1186/1758-5996-6-80 Text en © Gomes and Negrato; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Gomes, Marilia Brito
Negrato, Carlos Antonio
Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases
title Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases
title_full Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases
title_fullStr Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases
title_full_unstemmed Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases
title_short Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases
title_sort alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124142/
https://www.ncbi.nlm.nih.gov/pubmed/25104975
http://dx.doi.org/10.1186/1758-5996-6-80
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