Detection of Circulating Tumor Cells

The increasing number of treatment options for patients with metastatic carcinomas has created an accompanying need for methods to determine if the tumor will be responsive to the intended therapy and to monitor its effectiveness. Ideally, these methods would be noninvasive and provide quantitative...

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Detalles Bibliográficos
Autores principales: de Wit, Sanne, van Dalum, Guus, Terstappen, Leon W. M. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124199/
https://www.ncbi.nlm.nih.gov/pubmed/25133014
http://dx.doi.org/10.1155/2014/819362
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author de Wit, Sanne
van Dalum, Guus
Terstappen, Leon W. M. M.
author_facet de Wit, Sanne
van Dalum, Guus
Terstappen, Leon W. M. M.
author_sort de Wit, Sanne
collection PubMed
description The increasing number of treatment options for patients with metastatic carcinomas has created an accompanying need for methods to determine if the tumor will be responsive to the intended therapy and to monitor its effectiveness. Ideally, these methods would be noninvasive and provide quantitative real-time analysis of tumor activity in a variety of carcinomas. Assessment of circulating tumor cells shed into the blood during metastasis may satisfy this need. Here we review the CellSearch technology used for the detection of circulating tumor cells and discuss potential future directions for improvements.
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spelling pubmed-41241992014-08-17 Detection of Circulating Tumor Cells de Wit, Sanne van Dalum, Guus Terstappen, Leon W. M. M. Scientifica (Cairo) Review Article The increasing number of treatment options for patients with metastatic carcinomas has created an accompanying need for methods to determine if the tumor will be responsive to the intended therapy and to monitor its effectiveness. Ideally, these methods would be noninvasive and provide quantitative real-time analysis of tumor activity in a variety of carcinomas. Assessment of circulating tumor cells shed into the blood during metastasis may satisfy this need. Here we review the CellSearch technology used for the detection of circulating tumor cells and discuss potential future directions for improvements. Hindawi Publishing Corporation 2014 2014-07-15 /pmc/articles/PMC4124199/ /pubmed/25133014 http://dx.doi.org/10.1155/2014/819362 Text en Copyright © 2014 Sanne de Wit et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
de Wit, Sanne
van Dalum, Guus
Terstappen, Leon W. M. M.
Detection of Circulating Tumor Cells
title Detection of Circulating Tumor Cells
title_full Detection of Circulating Tumor Cells
title_fullStr Detection of Circulating Tumor Cells
title_full_unstemmed Detection of Circulating Tumor Cells
title_short Detection of Circulating Tumor Cells
title_sort detection of circulating tumor cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124199/
https://www.ncbi.nlm.nih.gov/pubmed/25133014
http://dx.doi.org/10.1155/2014/819362
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