The Alliance of Mesenchymal Stem Cells, Bone, and Diabetes

Bone fragility has emerged as a new complication of diabetes. Several mechanisms in diabetes may influence bone homeostasis by impairing the action between osteoblasts, osteoclasts, and osteocytes and/or changing the structural properties of the bone tissue. Some of these mechanisms can potentially...

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Detalles Bibliográficos
Autores principales: Napoli, Nicola, Strollo, Rocky, Paladini, Angela, Briganti, Silvia I., Pozzilli, Paolo, Epstein, Sol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124651/
https://www.ncbi.nlm.nih.gov/pubmed/25140176
http://dx.doi.org/10.1155/2014/690783
Descripción
Sumario:Bone fragility has emerged as a new complication of diabetes. Several mechanisms in diabetes may influence bone homeostasis by impairing the action between osteoblasts, osteoclasts, and osteocytes and/or changing the structural properties of the bone tissue. Some of these mechanisms can potentially alter the fate of mesenchymal stem cells, the initial precursor of the osteoblast. In this review, we describe the main factors that impair bone health in diabetic patients and their clinical impact.

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