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Chemical Composition, Leishmanicidal and Cytotoxic Activities of the Essential Oils from Mangifera indica L. var. Rosa and Espada
The essential oils from Mangifera indica var. Rosa and Espada latex were obtained by hydrodistillation and analyzed using GC-FID and GC-MS. Twenty-seven components were identified. The main compound in the essential oil from M. indica var. Espada (EOMiE) was terpinolene (73.6%). The essential oil of...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124710/ https://www.ncbi.nlm.nih.gov/pubmed/25136617 http://dx.doi.org/10.1155/2014/734946 |
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author | Ramos, Eduardo H. S. Moraes, Marcílio M. Nerys, Laís L. de A. Nascimento, Silene C. Militão, Gardênia C. G. de Figueiredo, Regina C. B. Q. da Câmara, Cláudio A. G. Silva, Teresinha Gonçalves |
author_facet | Ramos, Eduardo H. S. Moraes, Marcílio M. Nerys, Laís L. de A. Nascimento, Silene C. Militão, Gardênia C. G. de Figueiredo, Regina C. B. Q. da Câmara, Cláudio A. G. Silva, Teresinha Gonçalves |
author_sort | Ramos, Eduardo H. S. |
collection | PubMed |
description | The essential oils from Mangifera indica var. Rosa and Espada latex were obtained by hydrodistillation and analyzed using GC-FID and GC-MS. Twenty-seven components were identified. The main compound in the essential oil from M. indica var. Espada (EOMiE) was terpinolene (73.6%). The essential oil of M. indica var. Rosa (EOMiR) was characterized by high amounts of β-pinene (40.7%) and terpinolene (28.3%). In the test for leishmanicidal activity against promastigotes forms of L. amazonensis, EOMiR and EOMiE showed IC(50) (72 h) of 39.1 and 23.0 μg/mL, respectively. In macrophages, EOMiR and EOMiE showed CC(50) of 142.84 and 158.65 μg/mL, respectively. However, both were more specific to the parasite than macrophages, with values of selectivity index of 6.91 for EOMiE and 3.66 for EOMiR. The essential oils were evaluated for their cytotoxicity against the human tumor cells HEp-2, HT-29, NCI-H292, and HL-60. The EOMiR and EOMiE were most effective against the HL-60, with IC(50) values of 12.3 and 3.6 μg/mL, respectively. The results demonstrated that the essential oils of M. indica can destroy L. amazonensis and inhibit tumor cell growth. These findings contribute to the knowledge of the Brazilian biodiversity as a source of potential therapeutic agents. |
format | Online Article Text |
id | pubmed-4124710 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41247102014-08-18 Chemical Composition, Leishmanicidal and Cytotoxic Activities of the Essential Oils from Mangifera indica L. var. Rosa and Espada Ramos, Eduardo H. S. Moraes, Marcílio M. Nerys, Laís L. de A. Nascimento, Silene C. Militão, Gardênia C. G. de Figueiredo, Regina C. B. Q. da Câmara, Cláudio A. G. Silva, Teresinha Gonçalves Biomed Res Int Research Article The essential oils from Mangifera indica var. Rosa and Espada latex were obtained by hydrodistillation and analyzed using GC-FID and GC-MS. Twenty-seven components were identified. The main compound in the essential oil from M. indica var. Espada (EOMiE) was terpinolene (73.6%). The essential oil of M. indica var. Rosa (EOMiR) was characterized by high amounts of β-pinene (40.7%) and terpinolene (28.3%). In the test for leishmanicidal activity against promastigotes forms of L. amazonensis, EOMiR and EOMiE showed IC(50) (72 h) of 39.1 and 23.0 μg/mL, respectively. In macrophages, EOMiR and EOMiE showed CC(50) of 142.84 and 158.65 μg/mL, respectively. However, both were more specific to the parasite than macrophages, with values of selectivity index of 6.91 for EOMiE and 3.66 for EOMiR. The essential oils were evaluated for their cytotoxicity against the human tumor cells HEp-2, HT-29, NCI-H292, and HL-60. The EOMiR and EOMiE were most effective against the HL-60, with IC(50) values of 12.3 and 3.6 μg/mL, respectively. The results demonstrated that the essential oils of M. indica can destroy L. amazonensis and inhibit tumor cell growth. These findings contribute to the knowledge of the Brazilian biodiversity as a source of potential therapeutic agents. Hindawi Publishing Corporation 2014 2014-07-20 /pmc/articles/PMC4124710/ /pubmed/25136617 http://dx.doi.org/10.1155/2014/734946 Text en Copyright © 2014 Eduardo H. S. Ramos et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Ramos, Eduardo H. S. Moraes, Marcílio M. Nerys, Laís L. de A. Nascimento, Silene C. Militão, Gardênia C. G. de Figueiredo, Regina C. B. Q. da Câmara, Cláudio A. G. Silva, Teresinha Gonçalves Chemical Composition, Leishmanicidal and Cytotoxic Activities of the Essential Oils from Mangifera indica L. var. Rosa and Espada |
title | Chemical Composition, Leishmanicidal and Cytotoxic Activities of the Essential Oils from Mangifera indica L. var. Rosa and Espada |
title_full | Chemical Composition, Leishmanicidal and Cytotoxic Activities of the Essential Oils from Mangifera indica L. var. Rosa and Espada |
title_fullStr | Chemical Composition, Leishmanicidal and Cytotoxic Activities of the Essential Oils from Mangifera indica L. var. Rosa and Espada |
title_full_unstemmed | Chemical Composition, Leishmanicidal and Cytotoxic Activities of the Essential Oils from Mangifera indica L. var. Rosa and Espada |
title_short | Chemical Composition, Leishmanicidal and Cytotoxic Activities of the Essential Oils from Mangifera indica L. var. Rosa and Espada |
title_sort | chemical composition, leishmanicidal and cytotoxic activities of the essential oils from mangifera indica l. var. rosa and espada |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124710/ https://www.ncbi.nlm.nih.gov/pubmed/25136617 http://dx.doi.org/10.1155/2014/734946 |
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