Compare mDCs and pDCs between two distinct patients groups in acute HIV-1 infection

The role of DCs in primary HIV-1 infection remains uncertain. In this study, we enrolled two different groups of subjects with acute HIV-1 infection. One group progressed to CD4 counts below 200 cells/μl within 2 years of HIV-1 infection (CD4 Low Group), while the other group maintained CD4 counts a...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiao, Yanmei, Sun, Xin, Huang, Xiaojie, Li, Wei, Zhang, Tong, Wu, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124773/
https://www.ncbi.nlm.nih.gov/pubmed/25104967
http://dx.doi.org/10.1186/1742-6405-11-22
_version_ 1782329671583531008
author Jiao, Yanmei
Sun, Xin
Huang, Xiaojie
Li, Wei
Zhang, Tong
Wu, Hao
author_facet Jiao, Yanmei
Sun, Xin
Huang, Xiaojie
Li, Wei
Zhang, Tong
Wu, Hao
author_sort Jiao, Yanmei
collection PubMed
description The role of DCs in primary HIV-1 infection remains uncertain. In this study, we enrolled two different groups of subjects with acute HIV-1 infection. One group progressed to CD4 counts below 200 cells/μl within 2 years of HIV-1 infection (CD4 Low Group), while the other group maintained CD4 counts above 500 cells/μl (CD4 High Group). We did not find statistical difference in the pDC number between the two groups during acute HIV-1 infection. However, the mDC number was significantly lower in the CD4 Low Group than in the CD4 High Group.
format Online
Article
Text
id pubmed-4124773
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-41247732014-08-08 Compare mDCs and pDCs between two distinct patients groups in acute HIV-1 infection Jiao, Yanmei Sun, Xin Huang, Xiaojie Li, Wei Zhang, Tong Wu, Hao AIDS Res Ther Short Report The role of DCs in primary HIV-1 infection remains uncertain. In this study, we enrolled two different groups of subjects with acute HIV-1 infection. One group progressed to CD4 counts below 200 cells/μl within 2 years of HIV-1 infection (CD4 Low Group), while the other group maintained CD4 counts above 500 cells/μl (CD4 High Group). We did not find statistical difference in the pDC number between the two groups during acute HIV-1 infection. However, the mDC number was significantly lower in the CD4 Low Group than in the CD4 High Group. BioMed Central 2014-07-31 /pmc/articles/PMC4124773/ /pubmed/25104967 http://dx.doi.org/10.1186/1742-6405-11-22 Text en Copyright © 2014 Jiao et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Jiao, Yanmei
Sun, Xin
Huang, Xiaojie
Li, Wei
Zhang, Tong
Wu, Hao
Compare mDCs and pDCs between two distinct patients groups in acute HIV-1 infection
title Compare mDCs and pDCs between two distinct patients groups in acute HIV-1 infection
title_full Compare mDCs and pDCs between two distinct patients groups in acute HIV-1 infection
title_fullStr Compare mDCs and pDCs between two distinct patients groups in acute HIV-1 infection
title_full_unstemmed Compare mDCs and pDCs between two distinct patients groups in acute HIV-1 infection
title_short Compare mDCs and pDCs between two distinct patients groups in acute HIV-1 infection
title_sort compare mdcs and pdcs between two distinct patients groups in acute hiv-1 infection
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124773/
https://www.ncbi.nlm.nih.gov/pubmed/25104967
http://dx.doi.org/10.1186/1742-6405-11-22
work_keys_str_mv AT jiaoyanmei comparemdcsandpdcsbetweentwodistinctpatientsgroupsinacutehiv1infection
AT sunxin comparemdcsandpdcsbetweentwodistinctpatientsgroupsinacutehiv1infection
AT huangxiaojie comparemdcsandpdcsbetweentwodistinctpatientsgroupsinacutehiv1infection
AT liwei comparemdcsandpdcsbetweentwodistinctpatientsgroupsinacutehiv1infection
AT zhangtong comparemdcsandpdcsbetweentwodistinctpatientsgroupsinacutehiv1infection
AT wuhao comparemdcsandpdcsbetweentwodistinctpatientsgroupsinacutehiv1infection

Ejemplares similares