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Serum Interleukin 17 Levels in Patients with Crohn's Disease: Real Life Data
The aim of this study was to investigate serum IL17 levels in patients with Crohn's disease (CD) and to investigate the relationship between serum IL17 levels with disease activity. Methods. Fifty patients with CD and sex- and age-matched 40 healthy controls were included in the study. The seru...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124784/ https://www.ncbi.nlm.nih.gov/pubmed/25140070 http://dx.doi.org/10.1155/2014/690853 |
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author | Sahin, Abdurrahman Calhan, Turan Cengiz, Mustafa Kahraman, Resul Aydin, Kubra Ozdil, Kamil Korachi, May Sokmen, H. Mehmet |
author_facet | Sahin, Abdurrahman Calhan, Turan Cengiz, Mustafa Kahraman, Resul Aydin, Kubra Ozdil, Kamil Korachi, May Sokmen, H. Mehmet |
author_sort | Sahin, Abdurrahman |
collection | PubMed |
description | The aim of this study was to investigate serum IL17 levels in patients with Crohn's disease (CD) and to investigate the relationship between serum IL17 levels with disease activity. Methods. Fifty patients with CD and sex- and age-matched 40 healthy controls were included in the study. The serum IL17 levels, complete blood count, blood chemistry, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels were measured, and Crohn's disease activity was calculated using Crohn's disease activity index (CDAI). Results. The mean serum IL17 level of CD patients did not differ from those of healthy controls (P > 0.05). There was no difference between the mean serum IL levels of active CD patients and of quiescent CD patients (P > 0.05). However, the mean IL17 level of active patients was lower than of control subjects (P = 0.02). Serum IL17 was not correlated with inflammatory markers (ESR, CRP, white blood count, platelet count, and albumin) and CDAI. Conclusions. Peripheral blood serum IL17 levels of CD patients were not higher than of healthy controls, and also, serum IL17 level was not correlated with clinical disease activity. Peripheral IL17 measurement is not a useful tool for detecting and monitoring Crohn's disease which is understood to have complex etiopathogenesis. |
format | Online Article Text |
id | pubmed-4124784 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41247842014-08-19 Serum Interleukin 17 Levels in Patients with Crohn's Disease: Real Life Data Sahin, Abdurrahman Calhan, Turan Cengiz, Mustafa Kahraman, Resul Aydin, Kubra Ozdil, Kamil Korachi, May Sokmen, H. Mehmet Dis Markers Research Article The aim of this study was to investigate serum IL17 levels in patients with Crohn's disease (CD) and to investigate the relationship between serum IL17 levels with disease activity. Methods. Fifty patients with CD and sex- and age-matched 40 healthy controls were included in the study. The serum IL17 levels, complete blood count, blood chemistry, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels were measured, and Crohn's disease activity was calculated using Crohn's disease activity index (CDAI). Results. The mean serum IL17 level of CD patients did not differ from those of healthy controls (P > 0.05). There was no difference between the mean serum IL levels of active CD patients and of quiescent CD patients (P > 0.05). However, the mean IL17 level of active patients was lower than of control subjects (P = 0.02). Serum IL17 was not correlated with inflammatory markers (ESR, CRP, white blood count, platelet count, and albumin) and CDAI. Conclusions. Peripheral blood serum IL17 levels of CD patients were not higher than of healthy controls, and also, serum IL17 level was not correlated with clinical disease activity. Peripheral IL17 measurement is not a useful tool for detecting and monitoring Crohn's disease which is understood to have complex etiopathogenesis. Hindawi Publishing Corporation 2014 2014-07-16 /pmc/articles/PMC4124784/ /pubmed/25140070 http://dx.doi.org/10.1155/2014/690853 Text en Copyright © 2014 Abdurrahman Sahin et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Sahin, Abdurrahman Calhan, Turan Cengiz, Mustafa Kahraman, Resul Aydin, Kubra Ozdil, Kamil Korachi, May Sokmen, H. Mehmet Serum Interleukin 17 Levels in Patients with Crohn's Disease: Real Life Data |
title | Serum Interleukin 17 Levels in Patients with Crohn's Disease: Real Life Data |
title_full | Serum Interleukin 17 Levels in Patients with Crohn's Disease: Real Life Data |
title_fullStr | Serum Interleukin 17 Levels in Patients with Crohn's Disease: Real Life Data |
title_full_unstemmed | Serum Interleukin 17 Levels in Patients with Crohn's Disease: Real Life Data |
title_short | Serum Interleukin 17 Levels in Patients with Crohn's Disease: Real Life Data |
title_sort | serum interleukin 17 levels in patients with crohn's disease: real life data |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124784/ https://www.ncbi.nlm.nih.gov/pubmed/25140070 http://dx.doi.org/10.1155/2014/690853 |
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