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Serum Interleukin 17 Levels in Patients with Crohn's Disease: Real Life Data

The aim of this study was to investigate serum IL17 levels in patients with Crohn's disease (CD) and to investigate the relationship between serum IL17 levels with disease activity. Methods. Fifty patients with CD and sex- and age-matched 40 healthy controls were included in the study. The seru...

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Autores principales: Sahin, Abdurrahman, Calhan, Turan, Cengiz, Mustafa, Kahraman, Resul, Aydin, Kubra, Ozdil, Kamil, Korachi, May, Sokmen, H. Mehmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124784/
https://www.ncbi.nlm.nih.gov/pubmed/25140070
http://dx.doi.org/10.1155/2014/690853
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author Sahin, Abdurrahman
Calhan, Turan
Cengiz, Mustafa
Kahraman, Resul
Aydin, Kubra
Ozdil, Kamil
Korachi, May
Sokmen, H. Mehmet
author_facet Sahin, Abdurrahman
Calhan, Turan
Cengiz, Mustafa
Kahraman, Resul
Aydin, Kubra
Ozdil, Kamil
Korachi, May
Sokmen, H. Mehmet
author_sort Sahin, Abdurrahman
collection PubMed
description The aim of this study was to investigate serum IL17 levels in patients with Crohn's disease (CD) and to investigate the relationship between serum IL17 levels with disease activity. Methods. Fifty patients with CD and sex- and age-matched 40 healthy controls were included in the study. The serum IL17 levels, complete blood count, blood chemistry, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels were measured, and Crohn's disease activity was calculated using Crohn's disease activity index (CDAI). Results. The mean serum IL17 level of CD patients did not differ from those of healthy controls (P > 0.05). There was no difference between the mean serum IL levels of active CD patients and of quiescent CD patients (P > 0.05). However, the mean IL17 level of active patients was lower than of control subjects (P = 0.02). Serum IL17 was not correlated with inflammatory markers (ESR, CRP, white blood count, platelet count, and albumin) and CDAI. Conclusions. Peripheral blood serum IL17 levels of CD patients were not higher than of healthy controls, and also, serum IL17 level was not correlated with clinical disease activity. Peripheral IL17 measurement is not a useful tool for detecting and monitoring Crohn's disease which is understood to have complex etiopathogenesis.
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spelling pubmed-41247842014-08-19 Serum Interleukin 17 Levels in Patients with Crohn's Disease: Real Life Data Sahin, Abdurrahman Calhan, Turan Cengiz, Mustafa Kahraman, Resul Aydin, Kubra Ozdil, Kamil Korachi, May Sokmen, H. Mehmet Dis Markers Research Article The aim of this study was to investigate serum IL17 levels in patients with Crohn's disease (CD) and to investigate the relationship between serum IL17 levels with disease activity. Methods. Fifty patients with CD and sex- and age-matched 40 healthy controls were included in the study. The serum IL17 levels, complete blood count, blood chemistry, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels were measured, and Crohn's disease activity was calculated using Crohn's disease activity index (CDAI). Results. The mean serum IL17 level of CD patients did not differ from those of healthy controls (P > 0.05). There was no difference between the mean serum IL levels of active CD patients and of quiescent CD patients (P > 0.05). However, the mean IL17 level of active patients was lower than of control subjects (P = 0.02). Serum IL17 was not correlated with inflammatory markers (ESR, CRP, white blood count, platelet count, and albumin) and CDAI. Conclusions. Peripheral blood serum IL17 levels of CD patients were not higher than of healthy controls, and also, serum IL17 level was not correlated with clinical disease activity. Peripheral IL17 measurement is not a useful tool for detecting and monitoring Crohn's disease which is understood to have complex etiopathogenesis. Hindawi Publishing Corporation 2014 2014-07-16 /pmc/articles/PMC4124784/ /pubmed/25140070 http://dx.doi.org/10.1155/2014/690853 Text en Copyright © 2014 Abdurrahman Sahin et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sahin, Abdurrahman
Calhan, Turan
Cengiz, Mustafa
Kahraman, Resul
Aydin, Kubra
Ozdil, Kamil
Korachi, May
Sokmen, H. Mehmet
Serum Interleukin 17 Levels in Patients with Crohn's Disease: Real Life Data
title Serum Interleukin 17 Levels in Patients with Crohn's Disease: Real Life Data
title_full Serum Interleukin 17 Levels in Patients with Crohn's Disease: Real Life Data
title_fullStr Serum Interleukin 17 Levels in Patients with Crohn's Disease: Real Life Data
title_full_unstemmed Serum Interleukin 17 Levels in Patients with Crohn's Disease: Real Life Data
title_short Serum Interleukin 17 Levels in Patients with Crohn's Disease: Real Life Data
title_sort serum interleukin 17 levels in patients with crohn's disease: real life data
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124784/
https://www.ncbi.nlm.nih.gov/pubmed/25140070
http://dx.doi.org/10.1155/2014/690853
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