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Effects of Parity and Serum Prolactin Levels on the Incidence and Regression of DMBA-Induced Tumors in OFA hr/hr Rats

Prolactin (PRL) is a key player in the development of mammary cancer. We studied the effects of parity or hyperprolactinemia on mammary carcinogenesis in OFA hr/hr treated with 7,12-dimethylbenzanthracene. They were divided into three groups: nulliparous (Null), primiparous (PL, after pregnancy and...

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Autores principales: Sasso, Corina V., Santiano, Flavia E., López-Fontana, Constanza M., Pistone-Creydt, Virginia, Ezquer, Marcelo E., Hapon, María B., Jahn, Graciela A., Carón, Rubén W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124788/
https://www.ncbi.nlm.nih.gov/pubmed/25136563
http://dx.doi.org/10.1155/2014/210424
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author Sasso, Corina V.
Santiano, Flavia E.
López-Fontana, Constanza M.
Pistone-Creydt, Virginia
Ezquer, Marcelo E.
Hapon, María B.
Jahn, Graciela A.
Carón, Rubén W.
author_facet Sasso, Corina V.
Santiano, Flavia E.
López-Fontana, Constanza M.
Pistone-Creydt, Virginia
Ezquer, Marcelo E.
Hapon, María B.
Jahn, Graciela A.
Carón, Rubén W.
author_sort Sasso, Corina V.
collection PubMed
description Prolactin (PRL) is a key player in the development of mammary cancer. We studied the effects of parity or hyperprolactinemia on mammary carcinogenesis in OFA hr/hr treated with 7,12-dimethylbenzanthracene. They were divided into three groups: nulliparous (Null), primiparous (PL, after pregnancy and lactation), and hyperprolactinemic rats (I, implanted in the arcuate nucleus with 17β-estradiol). The tumor incidence was similar in the three groups. However, a higher percentage of regressing tumors was evident in the PL group. Serum PRL, mammary development, and mammary β-casein content were higher in I rats compared to Null. The expression of hormone receptors was similar in the different groups. However, mammary tissue from PL rats bearing tumors had increased expression of PRL and estrogen alpha receptors compared to rats free of tumors. Our results suggest that serum PRL levels do not have relevance on the incidence of tumors, probably because the low levels of PRL in OFA rats are not further decreased by PL like in other strains. However, supraphysiological levels of PRL affect carcinogenesis. PL induces regression of the tumors due to the differentiation produced on the mammary cells. Alterations in the expression of hormonal receptors may be involved in progression and regression of tumors.
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spelling pubmed-41247882014-08-18 Effects of Parity and Serum Prolactin Levels on the Incidence and Regression of DMBA-Induced Tumors in OFA hr/hr Rats Sasso, Corina V. Santiano, Flavia E. López-Fontana, Constanza M. Pistone-Creydt, Virginia Ezquer, Marcelo E. Hapon, María B. Jahn, Graciela A. Carón, Rubén W. Biomed Res Int Research Article Prolactin (PRL) is a key player in the development of mammary cancer. We studied the effects of parity or hyperprolactinemia on mammary carcinogenesis in OFA hr/hr treated with 7,12-dimethylbenzanthracene. They were divided into three groups: nulliparous (Null), primiparous (PL, after pregnancy and lactation), and hyperprolactinemic rats (I, implanted in the arcuate nucleus with 17β-estradiol). The tumor incidence was similar in the three groups. However, a higher percentage of regressing tumors was evident in the PL group. Serum PRL, mammary development, and mammary β-casein content were higher in I rats compared to Null. The expression of hormone receptors was similar in the different groups. However, mammary tissue from PL rats bearing tumors had increased expression of PRL and estrogen alpha receptors compared to rats free of tumors. Our results suggest that serum PRL levels do not have relevance on the incidence of tumors, probably because the low levels of PRL in OFA rats are not further decreased by PL like in other strains. However, supraphysiological levels of PRL affect carcinogenesis. PL induces regression of the tumors due to the differentiation produced on the mammary cells. Alterations in the expression of hormonal receptors may be involved in progression and regression of tumors. Hindawi Publishing Corporation 2014 2014-07-17 /pmc/articles/PMC4124788/ /pubmed/25136563 http://dx.doi.org/10.1155/2014/210424 Text en Copyright © 2014 Corina V. Sasso et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sasso, Corina V.
Santiano, Flavia E.
López-Fontana, Constanza M.
Pistone-Creydt, Virginia
Ezquer, Marcelo E.
Hapon, María B.
Jahn, Graciela A.
Carón, Rubén W.
Effects of Parity and Serum Prolactin Levels on the Incidence and Regression of DMBA-Induced Tumors in OFA hr/hr Rats
title Effects of Parity and Serum Prolactin Levels on the Incidence and Regression of DMBA-Induced Tumors in OFA hr/hr Rats
title_full Effects of Parity and Serum Prolactin Levels on the Incidence and Regression of DMBA-Induced Tumors in OFA hr/hr Rats
title_fullStr Effects of Parity and Serum Prolactin Levels on the Incidence and Regression of DMBA-Induced Tumors in OFA hr/hr Rats
title_full_unstemmed Effects of Parity and Serum Prolactin Levels on the Incidence and Regression of DMBA-Induced Tumors in OFA hr/hr Rats
title_short Effects of Parity and Serum Prolactin Levels on the Incidence and Regression of DMBA-Induced Tumors in OFA hr/hr Rats
title_sort effects of parity and serum prolactin levels on the incidence and regression of dmba-induced tumors in ofa hr/hr rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124788/
https://www.ncbi.nlm.nih.gov/pubmed/25136563
http://dx.doi.org/10.1155/2014/210424
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