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Combined compared to dissociated oral and intestinal sucrose stimuli induce different brain hedonic processes

The characterization of brain networks contributing to the processing of oral and/or intestinal sugar signals in a relevant animal model might help to understand the neural mechanisms related to the control of food intake in humans and suggest potential causes for impaired eating behaviors. This stu...

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Autores principales: Clouard, Caroline, Meunier-Salaün, Marie-Christine, Meurice, Paul, Malbert, Charles-Henri, Val-Laillet, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124794/
https://www.ncbi.nlm.nih.gov/pubmed/25147536
http://dx.doi.org/10.3389/fpsyg.2014.00861
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author Clouard, Caroline
Meunier-Salaün, Marie-Christine
Meurice, Paul
Malbert, Charles-Henri
Val-Laillet, David
author_facet Clouard, Caroline
Meunier-Salaün, Marie-Christine
Meurice, Paul
Malbert, Charles-Henri
Val-Laillet, David
author_sort Clouard, Caroline
collection PubMed
description The characterization of brain networks contributing to the processing of oral and/or intestinal sugar signals in a relevant animal model might help to understand the neural mechanisms related to the control of food intake in humans and suggest potential causes for impaired eating behaviors. This study aimed at comparing the brain responses triggered by oral and/or intestinal sucrose sensing in pigs. Seven animals underwent brain single photon emission computed tomography ((99m)Tc-HMPAO) further to oral stimulation with neutral or sucrose artificial saliva paired with saline or sucrose infusion in the duodenum, the proximal part of the intestine. Oral and/or duodenal sucrose sensing induced differential cerebral blood flow changes in brain regions known to be involved in memory, reward processes and hedonic (i.e., pleasure) evaluation of sensory stimuli, including the dorsal striatum, prefrontal cortex, cingulate cortex, insular cortex, hippocampus, and parahippocampal cortex. Sucrose duodenal infusion only and combined sucrose stimulation induced similar activity patterns in the putamen, ventral anterior cingulate cortex and hippocampus. Some brain deactivations in the prefrontal and insular cortices were only detected in the presence of oral sucrose stimulation. Finally, activation of the right insular cortex was only induced by combined oral and duodenal sucrose stimulation, while specific activity patterns were detected in the hippocampus and parahippocampal cortex with oral sucrose dissociated from caloric load. This study sheds new light on the brain hedonic responses to sugar and has potential implications to unravel the neuropsychological mechanisms underlying food pleasure and motivation.
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spelling pubmed-41247942014-08-21 Combined compared to dissociated oral and intestinal sucrose stimuli induce different brain hedonic processes Clouard, Caroline Meunier-Salaün, Marie-Christine Meurice, Paul Malbert, Charles-Henri Val-Laillet, David Front Psychol Psychology The characterization of brain networks contributing to the processing of oral and/or intestinal sugar signals in a relevant animal model might help to understand the neural mechanisms related to the control of food intake in humans and suggest potential causes for impaired eating behaviors. This study aimed at comparing the brain responses triggered by oral and/or intestinal sucrose sensing in pigs. Seven animals underwent brain single photon emission computed tomography ((99m)Tc-HMPAO) further to oral stimulation with neutral or sucrose artificial saliva paired with saline or sucrose infusion in the duodenum, the proximal part of the intestine. Oral and/or duodenal sucrose sensing induced differential cerebral blood flow changes in brain regions known to be involved in memory, reward processes and hedonic (i.e., pleasure) evaluation of sensory stimuli, including the dorsal striatum, prefrontal cortex, cingulate cortex, insular cortex, hippocampus, and parahippocampal cortex. Sucrose duodenal infusion only and combined sucrose stimulation induced similar activity patterns in the putamen, ventral anterior cingulate cortex and hippocampus. Some brain deactivations in the prefrontal and insular cortices were only detected in the presence of oral sucrose stimulation. Finally, activation of the right insular cortex was only induced by combined oral and duodenal sucrose stimulation, while specific activity patterns were detected in the hippocampus and parahippocampal cortex with oral sucrose dissociated from caloric load. This study sheds new light on the brain hedonic responses to sugar and has potential implications to unravel the neuropsychological mechanisms underlying food pleasure and motivation. Frontiers Media S.A. 2014-08-07 /pmc/articles/PMC4124794/ /pubmed/25147536 http://dx.doi.org/10.3389/fpsyg.2014.00861 Text en Copyright © 2014 Clouard, Meunier-Salaün, Meurice, Malbert and Val-Laillet. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychology
Clouard, Caroline
Meunier-Salaün, Marie-Christine
Meurice, Paul
Malbert, Charles-Henri
Val-Laillet, David
Combined compared to dissociated oral and intestinal sucrose stimuli induce different brain hedonic processes
title Combined compared to dissociated oral and intestinal sucrose stimuli induce different brain hedonic processes
title_full Combined compared to dissociated oral and intestinal sucrose stimuli induce different brain hedonic processes
title_fullStr Combined compared to dissociated oral and intestinal sucrose stimuli induce different brain hedonic processes
title_full_unstemmed Combined compared to dissociated oral and intestinal sucrose stimuli induce different brain hedonic processes
title_short Combined compared to dissociated oral and intestinal sucrose stimuli induce different brain hedonic processes
title_sort combined compared to dissociated oral and intestinal sucrose stimuli induce different brain hedonic processes
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124794/
https://www.ncbi.nlm.nih.gov/pubmed/25147536
http://dx.doi.org/10.3389/fpsyg.2014.00861
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