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Leptin and insulin signaling in dopaminergic neurons: relationship between energy balance and reward system
The central actions of leptin and insulin are essential for the regulation of energy and glucose homeostasis. In addition to the crucial effects on the hypothalamus, emerging evidence suggests that the leptin and insulin signaling can act on other brain regions to mediate the reward value of nutrien...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124796/ https://www.ncbi.nlm.nih.gov/pubmed/25147530 http://dx.doi.org/10.3389/fpsyg.2014.00846 |
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author | Khanh, Doan V. Choi, Yun-Hee Moh, Sang Hyun Kinyua, Ann W. Kim, Ki Woo |
author_facet | Khanh, Doan V. Choi, Yun-Hee Moh, Sang Hyun Kinyua, Ann W. Kim, Ki Woo |
author_sort | Khanh, Doan V. |
collection | PubMed |
description | The central actions of leptin and insulin are essential for the regulation of energy and glucose homeostasis. In addition to the crucial effects on the hypothalamus, emerging evidence suggests that the leptin and insulin signaling can act on other brain regions to mediate the reward value of nutrients. Recent studies have indicated the midbrain dopaminergic neurons as a potential site for leptin’ and insulin’s actions on mediating the feeding behaviors and therefore affecting the energy balance. Although molecular details about the integrative roles of leptin and insulin in this subset of neurons remain to be investigated, substantial body of evidence by far imply that the signaling pathways regulated by leptin and insulin may play an essential role in the regulation of energy balance through the control of food-associated reward. This review therefore describes the convergence of energy regulation and reward system, particularly focusing on leptin and insulin signaling in the midbrain dopaminergic neurons. |
format | Online Article Text |
id | pubmed-4124796 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-41247962014-08-21 Leptin and insulin signaling in dopaminergic neurons: relationship between energy balance and reward system Khanh, Doan V. Choi, Yun-Hee Moh, Sang Hyun Kinyua, Ann W. Kim, Ki Woo Front Psychol Psychology The central actions of leptin and insulin are essential for the regulation of energy and glucose homeostasis. In addition to the crucial effects on the hypothalamus, emerging evidence suggests that the leptin and insulin signaling can act on other brain regions to mediate the reward value of nutrients. Recent studies have indicated the midbrain dopaminergic neurons as a potential site for leptin’ and insulin’s actions on mediating the feeding behaviors and therefore affecting the energy balance. Although molecular details about the integrative roles of leptin and insulin in this subset of neurons remain to be investigated, substantial body of evidence by far imply that the signaling pathways regulated by leptin and insulin may play an essential role in the regulation of energy balance through the control of food-associated reward. This review therefore describes the convergence of energy regulation and reward system, particularly focusing on leptin and insulin signaling in the midbrain dopaminergic neurons. Frontiers Media S.A. 2014-08-07 /pmc/articles/PMC4124796/ /pubmed/25147530 http://dx.doi.org/10.3389/fpsyg.2014.00846 Text en Copyright © 2014 Khanh, Choi, Moh, Kinyua and Kim. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychology Khanh, Doan V. Choi, Yun-Hee Moh, Sang Hyun Kinyua, Ann W. Kim, Ki Woo Leptin and insulin signaling in dopaminergic neurons: relationship between energy balance and reward system |
title | Leptin and insulin signaling in dopaminergic neurons: relationship between energy balance and reward system |
title_full | Leptin and insulin signaling in dopaminergic neurons: relationship between energy balance and reward system |
title_fullStr | Leptin and insulin signaling in dopaminergic neurons: relationship between energy balance and reward system |
title_full_unstemmed | Leptin and insulin signaling in dopaminergic neurons: relationship between energy balance and reward system |
title_short | Leptin and insulin signaling in dopaminergic neurons: relationship between energy balance and reward system |
title_sort | leptin and insulin signaling in dopaminergic neurons: relationship between energy balance and reward system |
topic | Psychology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124796/ https://www.ncbi.nlm.nih.gov/pubmed/25147530 http://dx.doi.org/10.3389/fpsyg.2014.00846 |
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