Deoxycytidine Kinase Augments ATM-Mediated DNA Repair and Contributes to Radiation Resistance

Efficient and adequate generation of deoxyribonucleotides is critical to successful DNA repair. We show that ataxia telangiectasia mutated (ATM) integrates the DNA damage response with DNA metabolism by regulating the salvage of deoxyribonucleosides. Specifically, ATM phosphorylates and activates de...

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Detalles Bibliográficos
Autores principales: Bunimovich, Yuri L., Nair-Gill, Evan, Riedinger, Mireille, McCracken, Melissa N., Cheng, Donghui, McLaughlin, Jami, Radu, Caius G., Witte, Owen N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125169/
https://www.ncbi.nlm.nih.gov/pubmed/25101980
http://dx.doi.org/10.1371/journal.pone.0104125

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