Cargando…
In vivo transport of Gd-DTPA(2-) into human meniscus and cartilage assessed with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC)
BACKGROUND: Impaired stability is a risk factor in knee osteoarthritis (OA), where the whole joint and not only the joint cartilage is affected. The meniscus provides joint stability and is involved in the early pathological progress of OA. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) has...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125346/ https://www.ncbi.nlm.nih.gov/pubmed/25005036 http://dx.doi.org/10.1186/1471-2474-15-226 |
_version_ | 1782329767989608448 |
---|---|
author | Sigurdsson, Ulf Siversson, Carl Lammentausta, Eveliina Svensson, Jonas Tiderius, Carl-Johan Dahlberg, Leif E |
author_facet | Sigurdsson, Ulf Siversson, Carl Lammentausta, Eveliina Svensson, Jonas Tiderius, Carl-Johan Dahlberg, Leif E |
author_sort | Sigurdsson, Ulf |
collection | PubMed |
description | BACKGROUND: Impaired stability is a risk factor in knee osteoarthritis (OA), where the whole joint and not only the joint cartilage is affected. The meniscus provides joint stability and is involved in the early pathological progress of OA. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) has been used to identify pre-radiographic changes in the cartilage in OA, but has been used less commonly to examine the meniscus, and then using only a double dose of the contrast agent. The purpose of this study was to enable improved early OA diagnosis by investigate the temporal contrast agent distribution in the meniscus and femoral cartilage simultaneously, in healthy volunteers, using 3D dGEMRIC at two different doses of the contrast agent Gd-DTPA(2-). METHODS: The right knee in 12 asymptomatic volunteers was examined using a 3D Look-Locker sequence on two occasions after an intravenous injection of a double or triple dose of Gd-DTPA(2-) (0.2 or 0.3 mmol/kg body weight). The relaxation time (T(1)) and relaxation rate (R(1) = 1/T(1)) were measured in the meniscus and femoral cartilage before, and 60, 90, 120 and 180 minutes after injection, and the change in relaxation rate (ΔR(1)) was calculated. Paired t-test and Analysis of Variance (ANOVA) were used for statistical evaluation. RESULTS: The triple dose yielded higher concentrations of Gd-DTPA(2-) in the meniscus and cartilage than the double dose, but provided no additional information. The observed patterns of ΔR(1) were similar for double and triple doses of the contrast agent. ΔR(1) was higher in the meniscus than in femoral cartilage in the corresponding compartments at all time points after injection. ΔR(1) increased until 90-180 minutes in both the cartilage and the meniscus (p < 0.05), and was lower in the medial than in the lateral meniscus at all time points (p < 0.05). A faster increase in ΔR(1) was observed in the vascularized peripheral region of the posterior medial meniscus, than in the avascular central part of the posterior medial meniscus during the first 60 minutes (p < 0.05). CONCLUSION: It is feasible to examine undamaged meniscus and cartilage simultaneously using dGEMRIC, preferably 90 minutes after the injection of a double dose of Gd-DTPA(2-) (0.2 mmol/kg body weight). |
format | Online Article Text |
id | pubmed-4125346 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-41253462014-08-08 In vivo transport of Gd-DTPA(2-) into human meniscus and cartilage assessed with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) Sigurdsson, Ulf Siversson, Carl Lammentausta, Eveliina Svensson, Jonas Tiderius, Carl-Johan Dahlberg, Leif E BMC Musculoskelet Disord Research Article BACKGROUND: Impaired stability is a risk factor in knee osteoarthritis (OA), where the whole joint and not only the joint cartilage is affected. The meniscus provides joint stability and is involved in the early pathological progress of OA. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) has been used to identify pre-radiographic changes in the cartilage in OA, but has been used less commonly to examine the meniscus, and then using only a double dose of the contrast agent. The purpose of this study was to enable improved early OA diagnosis by investigate the temporal contrast agent distribution in the meniscus and femoral cartilage simultaneously, in healthy volunteers, using 3D dGEMRIC at two different doses of the contrast agent Gd-DTPA(2-). METHODS: The right knee in 12 asymptomatic volunteers was examined using a 3D Look-Locker sequence on two occasions after an intravenous injection of a double or triple dose of Gd-DTPA(2-) (0.2 or 0.3 mmol/kg body weight). The relaxation time (T(1)) and relaxation rate (R(1) = 1/T(1)) were measured in the meniscus and femoral cartilage before, and 60, 90, 120 and 180 minutes after injection, and the change in relaxation rate (ΔR(1)) was calculated. Paired t-test and Analysis of Variance (ANOVA) were used for statistical evaluation. RESULTS: The triple dose yielded higher concentrations of Gd-DTPA(2-) in the meniscus and cartilage than the double dose, but provided no additional information. The observed patterns of ΔR(1) were similar for double and triple doses of the contrast agent. ΔR(1) was higher in the meniscus than in femoral cartilage in the corresponding compartments at all time points after injection. ΔR(1) increased until 90-180 minutes in both the cartilage and the meniscus (p < 0.05), and was lower in the medial than in the lateral meniscus at all time points (p < 0.05). A faster increase in ΔR(1) was observed in the vascularized peripheral region of the posterior medial meniscus, than in the avascular central part of the posterior medial meniscus during the first 60 minutes (p < 0.05). CONCLUSION: It is feasible to examine undamaged meniscus and cartilage simultaneously using dGEMRIC, preferably 90 minutes after the injection of a double dose of Gd-DTPA(2-) (0.2 mmol/kg body weight). BioMed Central 2014-07-09 /pmc/articles/PMC4125346/ /pubmed/25005036 http://dx.doi.org/10.1186/1471-2474-15-226 Text en Copyright © 2014 Sigurdsson et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Sigurdsson, Ulf Siversson, Carl Lammentausta, Eveliina Svensson, Jonas Tiderius, Carl-Johan Dahlberg, Leif E In vivo transport of Gd-DTPA(2-) into human meniscus and cartilage assessed with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) |
title | In vivo transport of Gd-DTPA(2-) into human meniscus and cartilage assessed with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) |
title_full | In vivo transport of Gd-DTPA(2-) into human meniscus and cartilage assessed with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) |
title_fullStr | In vivo transport of Gd-DTPA(2-) into human meniscus and cartilage assessed with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) |
title_full_unstemmed | In vivo transport of Gd-DTPA(2-) into human meniscus and cartilage assessed with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) |
title_short | In vivo transport of Gd-DTPA(2-) into human meniscus and cartilage assessed with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) |
title_sort | in vivo transport of gd-dtpa(2-) into human meniscus and cartilage assessed with delayed gadolinium-enhanced mri of cartilage (dgemric) |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125346/ https://www.ncbi.nlm.nih.gov/pubmed/25005036 http://dx.doi.org/10.1186/1471-2474-15-226 |
work_keys_str_mv | AT sigurdssonulf invivotransportofgddtpa2intohumanmeniscusandcartilageassessedwithdelayedgadoliniumenhancedmriofcartilagedgemric AT siverssoncarl invivotransportofgddtpa2intohumanmeniscusandcartilageassessedwithdelayedgadoliniumenhancedmriofcartilagedgemric AT lammentaustaeveliina invivotransportofgddtpa2intohumanmeniscusandcartilageassessedwithdelayedgadoliniumenhancedmriofcartilagedgemric AT svenssonjonas invivotransportofgddtpa2intohumanmeniscusandcartilageassessedwithdelayedgadoliniumenhancedmriofcartilagedgemric AT tideriuscarljohan invivotransportofgddtpa2intohumanmeniscusandcartilageassessedwithdelayedgadoliniumenhancedmriofcartilagedgemric AT dahlbergleife invivotransportofgddtpa2intohumanmeniscusandcartilageassessedwithdelayedgadoliniumenhancedmriofcartilagedgemric |