Notch and TGFβ: Functional partners facilitating tumor progression

Cell signals integral to the tumor microenvironment influence cancer progression. Tumor-associated myeloid cells secrete pro-tumorigenic agents including, but not limited to, the potent cytokine transforming growth factor β (TGFβ). We have discovered a network of extrinsic signals including delta-li...

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Detalles Bibliográficos
Autores principales: Ohnuki, Hidetaka, Tosato, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126074/
https://www.ncbi.nlm.nih.gov/pubmed/25114830
http://dx.doi.org/10.4161/onci.29029
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author Ohnuki, Hidetaka
Tosato, Giovanna
author_facet Ohnuki, Hidetaka
Tosato, Giovanna
author_sort Ohnuki, Hidetaka
collection PubMed
description Cell signals integral to the tumor microenvironment influence cancer progression. Tumor-associated myeloid cells secrete pro-tumorigenic agents including, but not limited to, the potent cytokine transforming growth factor β (TGFβ). We have discovered a network of extrinsic signals including delta-like 4 (Dll4), Notch and TGFβ, linking malignant cells and tumor-infiltrating myeloid cells, a nexus portending a clinically-relevant anticancer treatment.
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spelling pubmed-41260742014-08-11 Notch and TGFβ: Functional partners facilitating tumor progression Ohnuki, Hidetaka Tosato, Giovanna Oncoimmunology Author's View Cell signals integral to the tumor microenvironment influence cancer progression. Tumor-associated myeloid cells secrete pro-tumorigenic agents including, but not limited to, the potent cytokine transforming growth factor β (TGFβ). We have discovered a network of extrinsic signals including delta-like 4 (Dll4), Notch and TGFβ, linking malignant cells and tumor-infiltrating myeloid cells, a nexus portending a clinically-relevant anticancer treatment. Landes Bioscience 2014-05-23 /pmc/articles/PMC4126074/ /pubmed/25114830 http://dx.doi.org/10.4161/onci.29029 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Ohnuki, Hidetaka
Tosato, Giovanna
Notch and TGFβ: Functional partners facilitating tumor progression
title Notch and TGFβ: Functional partners facilitating tumor progression
title_full Notch and TGFβ: Functional partners facilitating tumor progression
title_fullStr Notch and TGFβ: Functional partners facilitating tumor progression
title_full_unstemmed Notch and TGFβ: Functional partners facilitating tumor progression
title_short Notch and TGFβ: Functional partners facilitating tumor progression
title_sort notch and tgfβ: functional partners facilitating tumor progression
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126074/
https://www.ncbi.nlm.nih.gov/pubmed/25114830
http://dx.doi.org/10.4161/onci.29029
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