Histopathologic insights into the mechanism of anti-non-Gal antibody-mediated pig cardiac xenograft rejection

The histopathology of cardiac xenograft rejection has evolved over the last 20 yr with the development of new modalities for limiting antibody-mediated injury, advancing regimens for immune suppression, and an ever-widening variety of new donor genetics. These new technologies have helped us progres...

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Autores principales: Byrne, Guerard W, Azimzadeh, Agnes M, Ezzelarab, Mohamed, Tazelaar, Henry D, Ekser, Burcin, Pierson, Richard N, Robson, Simon C, Cooper, David K C, McGregor, Christopher G A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126170/
https://www.ncbi.nlm.nih.gov/pubmed/25098626
http://dx.doi.org/10.1111/xen.12050
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author Byrne, Guerard W
Azimzadeh, Agnes M
Ezzelarab, Mohamed
Tazelaar, Henry D
Ekser, Burcin
Pierson, Richard N
Robson, Simon C
Cooper, David K C
McGregor, Christopher G A
author_facet Byrne, Guerard W
Azimzadeh, Agnes M
Ezzelarab, Mohamed
Tazelaar, Henry D
Ekser, Burcin
Pierson, Richard N
Robson, Simon C
Cooper, David K C
McGregor, Christopher G A
author_sort Byrne, Guerard W
collection PubMed
description The histopathology of cardiac xenograft rejection has evolved over the last 20 yr with the development of new modalities for limiting antibody-mediated injury, advancing regimens for immune suppression, and an ever-widening variety of new donor genetics. These new technologies have helped us progress from what was once an overwhelming anti-Gal-mediated hyperacute rejection to a more protracted anti-Gal-mediated vascular rejection to what is now a more complex manifestation of non-Gal humoral rejection and coagulation dysregulation. This review summarizes the changing histopathology of Gal- and non-Gal-mediated cardiac xenograft rejection and discusses the contributions of immune-mediated injury, species-specific immune-independent factors, transplant and therapeutic procedures, and donor genetics to the overall mechanism(s) of cardiac xenograft rejection.
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spelling pubmed-41261702014-09-01 Histopathologic insights into the mechanism of anti-non-Gal antibody-mediated pig cardiac xenograft rejection Byrne, Guerard W Azimzadeh, Agnes M Ezzelarab, Mohamed Tazelaar, Henry D Ekser, Burcin Pierson, Richard N Robson, Simon C Cooper, David K C McGregor, Christopher G A Xenotransplantation Review The histopathology of cardiac xenograft rejection has evolved over the last 20 yr with the development of new modalities for limiting antibody-mediated injury, advancing regimens for immune suppression, and an ever-widening variety of new donor genetics. These new technologies have helped us progress from what was once an overwhelming anti-Gal-mediated hyperacute rejection to a more protracted anti-Gal-mediated vascular rejection to what is now a more complex manifestation of non-Gal humoral rejection and coagulation dysregulation. This review summarizes the changing histopathology of Gal- and non-Gal-mediated cardiac xenograft rejection and discusses the contributions of immune-mediated injury, species-specific immune-independent factors, transplant and therapeutic procedures, and donor genetics to the overall mechanism(s) of cardiac xenograft rejection. Blackwell Publishing Ltd 2013-09 2013-09-20 /pmc/articles/PMC4126170/ /pubmed/25098626 http://dx.doi.org/10.1111/xen.12050 Text en © 2013 John Wiley & Sons A/S http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Byrne, Guerard W
Azimzadeh, Agnes M
Ezzelarab, Mohamed
Tazelaar, Henry D
Ekser, Burcin
Pierson, Richard N
Robson, Simon C
Cooper, David K C
McGregor, Christopher G A
Histopathologic insights into the mechanism of anti-non-Gal antibody-mediated pig cardiac xenograft rejection
title Histopathologic insights into the mechanism of anti-non-Gal antibody-mediated pig cardiac xenograft rejection
title_full Histopathologic insights into the mechanism of anti-non-Gal antibody-mediated pig cardiac xenograft rejection
title_fullStr Histopathologic insights into the mechanism of anti-non-Gal antibody-mediated pig cardiac xenograft rejection
title_full_unstemmed Histopathologic insights into the mechanism of anti-non-Gal antibody-mediated pig cardiac xenograft rejection
title_short Histopathologic insights into the mechanism of anti-non-Gal antibody-mediated pig cardiac xenograft rejection
title_sort histopathologic insights into the mechanism of anti-non-gal antibody-mediated pig cardiac xenograft rejection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126170/
https://www.ncbi.nlm.nih.gov/pubmed/25098626
http://dx.doi.org/10.1111/xen.12050
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