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Applications of Magnetosomes Synthesized by Magnetotactic Bacteria in Medicine

Magnetotactic bacteria belong to a group of bacteria that synthesize iron oxide nanoparticles covered by biological material that are called magnetosomes. These bacteria use the magnetosomes as a compass to navigate in the direction of the earth’s magnetic field. This compass helps the bacteria to f...

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Autor principal: Alphandéry, Edouard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126476/
https://www.ncbi.nlm.nih.gov/pubmed/25152880
http://dx.doi.org/10.3389/fbioe.2014.00005
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author Alphandéry, Edouard
author_facet Alphandéry, Edouard
author_sort Alphandéry, Edouard
collection PubMed
description Magnetotactic bacteria belong to a group of bacteria that synthesize iron oxide nanoparticles covered by biological material that are called magnetosomes. These bacteria use the magnetosomes as a compass to navigate in the direction of the earth’s magnetic field. This compass helps the bacteria to find the optimum conditions for their growth and survival. Here, we review several medical applications of magnetosomes, such as those in magnetic resonance imaging (MRI), magnetic hyperthermia, and drug delivery. Different methods that can be used to prepare the magnetosomes for these applications are described. The toxicity and biodistribution results that have been published are summarized. They show that the magnetosomes can safely be used provided that they are prepared in specific conditions. The advantageous properties of the magnetosomes compared with those of chemically synthesized nanoparticles of similar composition are also highlighted.
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spelling pubmed-41264762014-08-22 Applications of Magnetosomes Synthesized by Magnetotactic Bacteria in Medicine Alphandéry, Edouard Front Bioeng Biotechnol Bioengineering and Biotechnology Magnetotactic bacteria belong to a group of bacteria that synthesize iron oxide nanoparticles covered by biological material that are called magnetosomes. These bacteria use the magnetosomes as a compass to navigate in the direction of the earth’s magnetic field. This compass helps the bacteria to find the optimum conditions for their growth and survival. Here, we review several medical applications of magnetosomes, such as those in magnetic resonance imaging (MRI), magnetic hyperthermia, and drug delivery. Different methods that can be used to prepare the magnetosomes for these applications are described. The toxicity and biodistribution results that have been published are summarized. They show that the magnetosomes can safely be used provided that they are prepared in specific conditions. The advantageous properties of the magnetosomes compared with those of chemically synthesized nanoparticles of similar composition are also highlighted. Frontiers Media S.A. 2014-03-11 /pmc/articles/PMC4126476/ /pubmed/25152880 http://dx.doi.org/10.3389/fbioe.2014.00005 Text en Copyright © 2014 Alphandéry. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Alphandéry, Edouard
Applications of Magnetosomes Synthesized by Magnetotactic Bacteria in Medicine
title Applications of Magnetosomes Synthesized by Magnetotactic Bacteria in Medicine
title_full Applications of Magnetosomes Synthesized by Magnetotactic Bacteria in Medicine
title_fullStr Applications of Magnetosomes Synthesized by Magnetotactic Bacteria in Medicine
title_full_unstemmed Applications of Magnetosomes Synthesized by Magnetotactic Bacteria in Medicine
title_short Applications of Magnetosomes Synthesized by Magnetotactic Bacteria in Medicine
title_sort applications of magnetosomes synthesized by magnetotactic bacteria in medicine
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126476/
https://www.ncbi.nlm.nih.gov/pubmed/25152880
http://dx.doi.org/10.3389/fbioe.2014.00005
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