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The rs225017 Polymorphism in the 3′UTR of the Human DIO2 Gene Is Associated with Increased Insulin Resistance
The Thr92Ala (rs225014) polymorphism in the type 2 deiodinase (DIO2) gene has been associated with insulin resistance (IR) and decreased enzyme activity in human tissues but kinetic studies failed to detect changes in the mutant enzyme, suggesting that this variant might be a marker of abnormal DIO2...
Autores principales: | Leiria, Leonardo B., Dora, José M., Wajner, Simone M., Estivalet, Aline A. F., Crispim, Daisy, Maia, Ana Luiza |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126657/ https://www.ncbi.nlm.nih.gov/pubmed/25105294 http://dx.doi.org/10.1371/journal.pone.0103960 |
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