Systemic CD8(+) T Cell-Mediated Tumoricidal Effects by Intratumoral Treatment of Oncolytic Herpes Simplex Virus with the Agonistic Monoclonal Antibody for Murine Glucocorticoid-Induced Tumor Necrosis Factor Receptor

Oncolytic virotherapy combined with immunomodulators is a novel noninvasive strategy for cancer treatment. In this study, we examined the tumoricidal effects of oncolytic HF10, a naturally occurring mutant of herpes simplex virus type-1, combined with an agonistic DTA-1 monoclonal antibody specific...

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Detalles Bibliográficos
Autores principales: Ishihara, Mikiya, Seo, Naohiro, Mitsui, Jun, Muraoka, Daisuke, Tanaka, Maki, Mineno, Junichi, Ikeda, Hiroaki, Shiku, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126744/
https://www.ncbi.nlm.nih.gov/pubmed/25105508
http://dx.doi.org/10.1371/journal.pone.0104669

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