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Functional Vascular Study in Hypertensive Subjects with Type 2 Diabetes Using Losartan or Amlodipine
BACKGROUND: Antihypertensive drugs are used to control blood pressure (BP) and reduce macro- and microvascular complications in hypertensive patients with diabetes. OBJECTIVES: The present study aimed to compare the functional vascular changes in hypertensive patients with type 2 diabetes mellitus a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Cardiologia
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126761/ https://www.ncbi.nlm.nih.gov/pubmed/25014057 http://dx.doi.org/10.5935/abc.20140089 |
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author | Pozzobon, Cesar Romaro Gismondi, Ronaldo A. O. C. Bedirian, Ricardo Ladeira, Marcia Cristina Neves, Mario Fritsch Oigman, Wille |
author_facet | Pozzobon, Cesar Romaro Gismondi, Ronaldo A. O. C. Bedirian, Ricardo Ladeira, Marcia Cristina Neves, Mario Fritsch Oigman, Wille |
author_sort | Pozzobon, Cesar Romaro |
collection | PubMed |
description | BACKGROUND: Antihypertensive drugs are used to control blood pressure (BP) and reduce macro- and microvascular complications in hypertensive patients with diabetes. OBJECTIVES: The present study aimed to compare the functional vascular changes in hypertensive patients with type 2 diabetes mellitus after 6 weeks of treatment with amlodipine or losartan. METHODS: Patients with a previous diagnosis of hypertension and type 2 diabetes mellitus were randomly divided into 2 groups and evaluated after 6 weeks of treatment with amlodipine (5 mg/day) or losartan (100 mg/day). Patient evaluation included BP measurement, ambulatory BP monitoring, and assessment of vascular parameters using applanation tonometry, pulse wave velocity (PWV), and flow-mediated dilation (FMD) of the brachial artery. RESULTS: A total of 42 patients were evaluated (21 in each group), with a predominance of women (71%) in both groups. The mean age of the patients in both groups was similar (amlodipine group: 54.9 ± 4.5 years; losartan group: 54.0 ± 6.9 years), with no significant difference in the mean BP [amlodipine group: 145 ± 14 mmHg (systolic) and 84 ± 8 mmHg (diastolic); losartan group: 153 ± 19 mmHg (systolic) and 90 ± 9 mmHg (diastolic)]. The augmentation index (30% ± 9% and 36% ± 8%, p = 0.025) and augmentation pressure (16 ± 6 mmHg and 20 ± 8 mmHg, p = 0.045) were lower in the amlodipine group when compared with the losartan group. PWV and FMD were similar in both groups. CONCLUSIONS: Hypertensive patients with type 2 diabetes mellitus treated with amlodipine exhibited an improved pattern of pulse wave reflection in comparison with those treated with losartan. However, the use of losartan may be associated with independent vascular reactivity to the pressor effect. |
format | Online Article Text |
id | pubmed-4126761 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Sociedade Brasileira de Cardiologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-41267612014-08-11 Functional Vascular Study in Hypertensive Subjects with Type 2 Diabetes Using Losartan or Amlodipine Pozzobon, Cesar Romaro Gismondi, Ronaldo A. O. C. Bedirian, Ricardo Ladeira, Marcia Cristina Neves, Mario Fritsch Oigman, Wille Arq Bras Cardiol Original Articles BACKGROUND: Antihypertensive drugs are used to control blood pressure (BP) and reduce macro- and microvascular complications in hypertensive patients with diabetes. OBJECTIVES: The present study aimed to compare the functional vascular changes in hypertensive patients with type 2 diabetes mellitus after 6 weeks of treatment with amlodipine or losartan. METHODS: Patients with a previous diagnosis of hypertension and type 2 diabetes mellitus were randomly divided into 2 groups and evaluated after 6 weeks of treatment with amlodipine (5 mg/day) or losartan (100 mg/day). Patient evaluation included BP measurement, ambulatory BP monitoring, and assessment of vascular parameters using applanation tonometry, pulse wave velocity (PWV), and flow-mediated dilation (FMD) of the brachial artery. RESULTS: A total of 42 patients were evaluated (21 in each group), with a predominance of women (71%) in both groups. The mean age of the patients in both groups was similar (amlodipine group: 54.9 ± 4.5 years; losartan group: 54.0 ± 6.9 years), with no significant difference in the mean BP [amlodipine group: 145 ± 14 mmHg (systolic) and 84 ± 8 mmHg (diastolic); losartan group: 153 ± 19 mmHg (systolic) and 90 ± 9 mmHg (diastolic)]. The augmentation index (30% ± 9% and 36% ± 8%, p = 0.025) and augmentation pressure (16 ± 6 mmHg and 20 ± 8 mmHg, p = 0.045) were lower in the amlodipine group when compared with the losartan group. PWV and FMD were similar in both groups. CONCLUSIONS: Hypertensive patients with type 2 diabetes mellitus treated with amlodipine exhibited an improved pattern of pulse wave reflection in comparison with those treated with losartan. However, the use of losartan may be associated with independent vascular reactivity to the pressor effect. Sociedade Brasileira de Cardiologia 2014-07 /pmc/articles/PMC4126761/ /pubmed/25014057 http://dx.doi.org/10.5935/abc.20140089 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Pozzobon, Cesar Romaro Gismondi, Ronaldo A. O. C. Bedirian, Ricardo Ladeira, Marcia Cristina Neves, Mario Fritsch Oigman, Wille Functional Vascular Study in Hypertensive Subjects with Type 2 Diabetes Using Losartan or Amlodipine |
title | Functional Vascular Study in Hypertensive Subjects with Type 2
Diabetes Using Losartan or Amlodipine |
title_full | Functional Vascular Study in Hypertensive Subjects with Type 2
Diabetes Using Losartan or Amlodipine |
title_fullStr | Functional Vascular Study in Hypertensive Subjects with Type 2
Diabetes Using Losartan or Amlodipine |
title_full_unstemmed | Functional Vascular Study in Hypertensive Subjects with Type 2
Diabetes Using Losartan or Amlodipine |
title_short | Functional Vascular Study in Hypertensive Subjects with Type 2
Diabetes Using Losartan or Amlodipine |
title_sort | functional vascular study in hypertensive subjects with type 2
diabetes using losartan or amlodipine |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126761/ https://www.ncbi.nlm.nih.gov/pubmed/25014057 http://dx.doi.org/10.5935/abc.20140089 |
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