Cargando…

In Vitro and In Vivo Evaluation of a Hydrogel Reservoir as a Continuous Drug Delivery System for Inner Ear Treatment

Fibrous tissue growth and loss of residual hearing after cochlear implantation can be reduced by application of the glucocorticoid dexamethasone-21-phosphate-disodium-salt (DEX). To date, sustained delivery of this agent to the cochlea using a number of pharmaceutical technologies has not been entir...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hütten, Mareike, Dhanasingh, Anandhan, Hessler, Roland, Stöver, Timo, Esser, Karl-Heinz, Möller, Martin, Lenarz, Thomas, Jolly, Claude, Groll, Jürgen, Scheper, Verena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126769/ https://www.ncbi.nlm.nih.gov/pubmed/25105670 http://dx.doi.org/10.1371/journal.pone.0104564

Ejemplares similares

Local inner ear application of dexamethasone in cochlear implant models is safe for auditory neurons and increases the neuroprotective effect of chronic electrical stimulation
por: Scheper, Verena, et al.
Publicado: (2017)

A novel cochlear measurement that predicts inner-ear malformation
por: Khurayzi, Tawfiq, et al.
Publicado: (2021)

Method to estimate the basal turn length in inner ear malformation types
por: Alshalan, Afrah, et al.
Publicado: (2023)

In Situ 3D-Imaging of the Inner Ear Synapses with a Cochlear Implant
por: Malfeld, Kathrin, et al.
Publicado: (2021)

Review on cochlear implant electrode array tip fold-over and scalar deviation
por: Dhanasingh, Anandhan, et al.
Publicado: (2019)

Internal auditory canal volume in normal and malformed inner ears
por: Bächinger, David, et al.
Publicado: (2022)

Dexamethasone for Inner Ear Therapy: Biocompatibility and Bio-Efficacy of Different Dexamethasone Formulations In Vitro
por: Gao, Ziwen, et al.
Publicado: (2021)

Uncoiling the Human Cochlea—Physical Scala Tympani Models to Study Pharmacokinetics Inside the Inner Ear
por: Schurzig, Daniel, et al.
Publicado: (2021)

Volumetry improves the assessment of the vestibular aqueduct size in inner ear malformation
por: Weiss, Nora M., et al.
Publicado: (2022)

A novel three‐step process for the identification of inner ear malformation types
por: Dhanasingh, Anandhan E., et al.
Publicado: (2022)

Impedance Changes and Fibrous Tissue Growth after Cochlear Implantation Are Correlated and Can Be Reduced Using a Dexamethasone Eluting Electrode
por: Wilk, Maciej, et al.
Publicado: (2016)

3D Printed Cell Culture Chamber for Testing the Effect of Pump-Based Chronic Drug Delivery on Inner Ear Tissue
por: Schwieger, Jana, et al.
Publicado: (2022)

A novel method of identifying inner ear malformation types by pattern recognition in the mid modiolar section
por: Dhanasingh, Anandhan, et al.
Publicado: (2021)

Local Long-Term Inner Ear Drug Delivery in Normal Hearing Guinea Pig—An Animal Model to Develop Preventive Treatment for Noise-Induced Hearing Loss
por: Malfeld, Kathrin, et al.
Publicado: (2022)

Prevention of Noise-Induced Hearing Loss In Vivo: Continuous Application of Insulin-like Growth Factor 1 and Its Effect on Inner Ear Synapses, Auditory Function and Perilymph Proteins
por: Malfeld, Kathrin, et al.
Publicado: (2022)

Cochlear Dummy Electrodes for Insertion Training and Research Purposes: Fabrication, Mechanical Characterization, and Experimental Validation
por: Kobler, Jan-Philipp, et al.
Publicado: (2015)

Literature Review on the Distribution of Spiral Ganglion Cell Bodies inside the Human Cochlear Central Modiolar Trunk
por: Dhanasingh, Anandhan, et al.
Publicado: (2020)

Consecutive Treatment with Brain-Derived Neurotrophic Factor and Electrical Stimulation Has a Protective Effect on Primary Auditory Neurons
por: Scheper, Verena, et al.
Publicado: (2020)

Neuronal Survival, Morphology and Outgrowth of Spiral Ganglion Neurons Using a Defined Growth Factor Combination
por: Schwieger, Jana, et al.
Publicado: (2015)

Neural representation in the auditory midbrain of the envelope of vocalizations based on a peripheral ear model
por: Rode, Thilo, et al.
Publicado: (2013)

Cochlear duct length along the outer wall vs organ of corti: Which one is relevant for the electrode array length selection and frequency mapping using Greenwood function?
por: Dhanasingh, Anandhan
Publicado: (2018)

Variations in the Size and Shape of Human Cochlear Malformation Types
por: Dhanasingh, Anandhan
Publicado: (2019)

The rationale for FLEX (cochlear implant) electrode with varying array lengths
por: Dhanasingh, Anandhan
Publicado: (2020)

Research software in cochlear duct length estimation, Greenwood frequency mapping and CI electrode array length simulation
por: Dhanasingh, Anandhan
Publicado: (2020)

Stimulation efficiency of an actuator driven piston at the biological interface to the inner ear
por: Busch, Susan, et al.
Publicado: (2021)

Development and In-Silico and Ex-Vivo Validation of a Software for a Semi-Automated Segmentation of the Round Window Niche to Design a Patient Specific Implant to Treat Inner Ear Disorders
por: Matin-Mann, Farnaz, et al.
Publicado: (2023)

Imaging cochlear implantation with round window insertion in human temporal bones and cochlear morphological variation using high-resolution cone beam CT
por: Zou, Jing, et al.
Publicado: (2015)

Nanosecond laser pulse stimulation of the inner ear—a wavelength study
por: Schultz, Michael, et al.
Publicado: (2012)

A potential serological biomarker for inner ear pathologies: OTOLIN-1
por: Avallone, Emilio, et al.
Publicado: (2022)

In vitro impact of platinum nanoparticles on inner ear related cell culture models
por: Berger, Elisabeth, et al.
Publicado: (2023)

Treatment of Middle Ear Ventilation Disorders: Sheep as Animal Model for Stenting the Human Eustachian Tube – A Cadaver Study
por: Miller, Felicitas, et al.
Publicado: (2014)

Lipidic nanocapsule drug delivery: neuronal protection for cochlear implant optimization
por: Meyer, Hartwig, et al.
Publicado: (2012)

Three-dimensional histological specimen preparation for accurate imaging and spatial reconstruction of the middle and inner ear
por: Rau, Thomas S., et al.
Publicado: (2013)

Inner Ear
por: Arnold, Andreas, et al.
Publicado: (2010)

The Conspicuous Link between Ear, Brain and Heart–Could Neurotrophin-Treatment of Age-Related Hearing Loss Help Prevent Alzheimer’s Disease and Associated Amyloid Cardiomyopathy?
por: Shityakov, Sergey, et al.
Publicado: (2021)

Extracellular Vesicles in Inner Ear Therapies—Pathophysiological, Manufacturing, and Clinical Considerations
por: Warnecke, Athanasia, et al.
Publicado: (2022)

Preclinical evaluation of thermoreversible triamcinolone acetonide hydrogels for drug delivery to the inner ear
por: Engleder, Elisabeth, et al.
Publicado: (2014)

Deep intracochlear injection of triamcinolone-acetonide with an inner ear catheter in patients with residual hearing
por: Prenzler, Nils K., et al.
Publicado: (2023)

Monitoring of the Inner Ear Function During and After Cochlear Implant Insertion Using Electrocochleography
por: Haumann, Sabine, et al.
Publicado: (2019)

Editorial: Alterations of Vestibular Function in Cochlear Implantation
por: Dhanasingh, Anandhan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_nuuvjaeman7p8p8edsf07n8ius