Targeting COX-2 abrogates mammary tumorigenesis: Breaking cancer-associated suppression of immunosurveillance

Three studies addressed the role of cyclooxygenase-2 (COX-2) in mammary tumorigenesis using epithelial and macrophage COX-2 knockout mice. Deletion of COX-2 in either cell restored, at least partially, tumor immunosurveillance either by changing macrophage function to offset pro-tumor effects, or by...

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Autores principales: Markosyan, Nune, Chen, Edward P, Smyth, Emer M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126836/
https://www.ncbi.nlm.nih.gov/pubmed/25114833
http://dx.doi.org/10.4161/onci.29287
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author Markosyan, Nune
Chen, Edward P
Smyth, Emer M
author_facet Markosyan, Nune
Chen, Edward P
Smyth, Emer M
author_sort Markosyan, Nune
collection PubMed
description Three studies addressed the role of cyclooxygenase-2 (COX-2) in mammary tumorigenesis using epithelial and macrophage COX-2 knockout mice. Deletion of COX-2 in either cell restored, at least partially, tumor immunosurveillance either by changing macrophage function to offset pro-tumor effects, or by attracting more cytotoxic T lymphocytes and natural killer cells to the tumor. These studies suggest benefits from targeted COX-2 selective inhibition in combination with immunotherapies.
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spelling pubmed-41268362014-08-11 Targeting COX-2 abrogates mammary tumorigenesis: Breaking cancer-associated suppression of immunosurveillance Markosyan, Nune Chen, Edward P Smyth, Emer M Oncoimmunology Author's View Three studies addressed the role of cyclooxygenase-2 (COX-2) in mammary tumorigenesis using epithelial and macrophage COX-2 knockout mice. Deletion of COX-2 in either cell restored, at least partially, tumor immunosurveillance either by changing macrophage function to offset pro-tumor effects, or by attracting more cytotoxic T lymphocytes and natural killer cells to the tumor. These studies suggest benefits from targeted COX-2 selective inhibition in combination with immunotherapies. Landes Bioscience 2014-06-30 /pmc/articles/PMC4126836/ /pubmed/25114833 http://dx.doi.org/10.4161/onci.29287 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Markosyan, Nune
Chen, Edward P
Smyth, Emer M
Targeting COX-2 abrogates mammary tumorigenesis: Breaking cancer-associated suppression of immunosurveillance
title Targeting COX-2 abrogates mammary tumorigenesis: Breaking cancer-associated suppression of immunosurveillance
title_full Targeting COX-2 abrogates mammary tumorigenesis: Breaking cancer-associated suppression of immunosurveillance
title_fullStr Targeting COX-2 abrogates mammary tumorigenesis: Breaking cancer-associated suppression of immunosurveillance
title_full_unstemmed Targeting COX-2 abrogates mammary tumorigenesis: Breaking cancer-associated suppression of immunosurveillance
title_short Targeting COX-2 abrogates mammary tumorigenesis: Breaking cancer-associated suppression of immunosurveillance
title_sort targeting cox-2 abrogates mammary tumorigenesis: breaking cancer-associated suppression of immunosurveillance
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126836/
https://www.ncbi.nlm.nih.gov/pubmed/25114833
http://dx.doi.org/10.4161/onci.29287
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