Asfotase-α improves bone growth, mineralization and strength in mouse models of neurofibromatosis type-1

Mineralization of the skeleton depends on the balance between levels of pyrophosphate (PPi), an inhibitor of hydroxyapatite formation, and phosphate generated from PPi breakdown by alkaline phosphatase (ALP). We report here that ablation of Nf1, encoding the RAS/GTPase–activating protein neurofibrom...

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Detalles Bibliográficos
Autores principales: de la Croix Ndong, Jean, Makowski, Alexander James, Uppuganti, Sasidhar, Vignaux, Guillaume, Ono, Koichiro, Perrien, Daniel S., Joubert, Simon, Baglio, Serena R., Granchi, Donatella, Stevenson, David A., Rios, Jonathan J., Nyman, Jeffry S., Elefteriou, Florent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126855/
https://www.ncbi.nlm.nih.gov/pubmed/24997609
http://dx.doi.org/10.1038/nm.3583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126855/
https://www.ncbi.nlm.nih.gov/pubmed/24997609
http://dx.doi.org/10.1038/nm.3583

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