The use of transformed IMR90 cell model to identify the potential extra-telomeric effects of hTERT in cell migration and DNA damage response

BACKGROUND: Human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomesase, is responsible for telomere maintenance and its reactivation is implicated in almost 90% human cancers. Recent evidences show that hTERT is essential for neoplastic transformation independent of its cano...

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Detalles Bibliográficos
Autores principales: Cao, Xu, Kong, Chiou Mee, Mathi, Kanchi Madhu, Lim, Yoon Pin, Cacheux-Rataboul, Valere, Wang, Xueying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126993/
https://www.ncbi.nlm.nih.gov/pubmed/25098897
http://dx.doi.org/10.1186/1471-2091-15-17

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