Cargando…

c-kit(+) Cells Minimally Contribute Cardiomyocytes to the Heart

If and how the heart regenerates after an injury event is highly debated. c-kit-expressing cardiac progenitor cells have been reported as the primary source for generation of new myocardium after injury. Here we generated two genetic approaches in mice to examine if endogenous c-kit(+) cells contrib...

Descripción completa

Detalles Bibliográficos
Autores principales:	van Berlo, Jop H., Kanisicak, Onur, Maillet, Marjorie, Vagnozzi, Ronald J., Karch, Jason, Lin, Suh-Chin J., Middleton, Ryan C., Marbán, Eduardo, Molkentin, Jeffery D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127035/ https://www.ncbi.nlm.nih.gov/pubmed/24805242 http://dx.doi.org/10.1038/nature13309

Ejemplares similares

Gata4-Dependent Differentiation of c-Kit(+)–Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart
por: Maliken, Bryan D., et al.
Publicado: (2018)

BEX1 is an RNA-dependent mediator of cardiomyopathy
por: Accornero, Federica, et al.
Publicado: (2017)

Applying Modern Transcriptomics to Interrogate the Human Cardiac Fibroblast
por: Kanisicak, Onur, et al.
Publicado: (2016)

Parsing the Roles of the Transcription Factors GATA-4 and GATA-6 in the Adult Cardiac Hypertrophic Response
por: van Berlo, Jop H., et al.
Publicado: (2013)

Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death
por: Karch, Jason, et al.
Publicado: (2015)

Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak
por: Karch, Jason, et al.
Publicado: (2017)

Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart
por: Fu, Xing, et al.
Publicado: (2018)

Genetic lineage tracing defines myofibroblast origin and function in the injured heart
por: Kanisicak, Onur, et al.
Publicado: (2016)

An acute immune response underlies the benefit of cardiac stem cell therapy
por: Vagnozzi, Ronald J., et al.
Publicado: (2019)

Stimulation of Cardiomyocyte Proliferation Is Dependent on Species and Level of Maturation
por: Yücel, Dogacan, et al.
Publicado: (2022)

Cell-specific ablation of Hsp47 defines the collagen-producing cells in the injured heart
por: Khalil, Hadi, et al.
Publicado: (2019)

Evidence for Minimal Cardiogenic Potential of Stem Cell Antigen 1–Positive Cells in the Adult Mouse Heart
por: Neidig, Lauren E., et al.
Publicado: (2018)

Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability
por: Schips, Tobias G., et al.
Publicado: (2019)

Newt cells secrete extracellular vesicles with therapeutic bioactivity in mammalian cardiomyocytes
por: Middleton, Ryan C., et al.
Publicado: (2018)

The Role of Cardiac Side Population Cells in Cardiac Regeneration
por: Yellamilli, Amritha, et al.
Publicado: (2016)

Unraveling the complexities of cardiac remodeling and hypertrophy — High-content screening and computational modeling
por: Elrod, John W., et al.
Publicado: (2014)

PKCα regulates the hypertrophic growth of cardiomyocytes through extracellular signal–regulated kinase1/2 (ERK1/2)
por: Braz, Julian C., et al.
Publicado: (2002)

Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter the cell cycle
por: Matsuura, Katsuhisa, et al.
Publicado: (2004)

Angiogenesis, Cardiomyocyte Proliferation and Anti-Fibrotic Effects Underlie Structural Preservation Post-Infarction by Intramyocardially-Injected Cardiospheres
por: Tseliou, Eleni, et al.
Publicado: (2014)

Macrophages Remember When Your Heart Was Broken
por: Souza-Neto, Fernando, et al.
Publicado: (2023)

Relative Roles of CD90 and c‐Kit to the Regenerative Efficacy of Cardiosphere‐Derived Cells in Humans and in a Mouse Model of Myocardial Infarction
por: Cheng, Ke, et al.
Publicado: (2014)

Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes
por: Liu, Qiaozhen, et al.
Publicado: (2016)

Impact of circadian time of dosing on cardiomyocyte-autonomous effects of glucocorticoids
por: Wintzinger, Michelle, et al.
Publicado: (2022)

Heart-specific Deletion of CnB1 Reveals Multiple Mechanisms Whereby Calcineurin Regulates Cardiac Growth and Function
por: Maillet, Marjorie, et al.
Publicado: (2010)

Dedifferentiation and Proliferation of Mammalian Cardiomyocytes
por: Zhang, Yiqiang, et al.
Publicado: (2010)

Epigenomic Reprogramming of Adult Cardiomyocyte-Derived Cardiac Progenitor Cells
por: Zhang, Yiqiang, et al.
Publicado: (2015)

PIM1 Promotes Survival of Cardiomyocytes by Upregulating c-Kit Protein Expression
por: Ebeid, David E., et al.
Publicado: (2020)

ANT-dependent MPTP underlies necrotic myofiber death in muscular dystrophy
por: Bround, Michael J., et al.
Publicado: (2023)

Corrigendum: Epigenomic Reprogramming of Adult Cardiomyocyte-Derived Cardiac Progenitor Cells
por: Zhang, Yiqiang, et al.
Publicado: (2017)

Postnatal Ablation of Foxm1 from Cardiomyocytes Causes Late Onset Cardiac Hypertrophy and Fibrosis without Exacerbating Pressure Overload-Induced Cardiac Remodeling
por: Bolte, Craig, et al.
Publicado: (2012)

Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart
por: Liu, Ruijie, et al.
Publicado: (2016)

Thrombospondin expression in myofibers stabilizes muscle membranes
por: Vanhoutte, Davy, et al.
Publicado: (2016)

Inhibition of Senescence‐Associated Genes Rb1 and Meis2 in Adult Cardiomyocytes Results in Cell Cycle Reentry and Cardiac Repair Post–Myocardial Infarction
por: Alam, Perwez, et al.
Publicado: (2019)

Charged Residues between the Selectivity Filter and S6 Segments Contribute to the Permeation Phenotype of the Sodium Channel
por: Li, Ronald A., et al.
Publicado: (2000)

Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD
por: Karch, Jason, et al.
Publicado: (2019)

Expression of Foxm1 Transcription Factor in Cardiomyocytes Is Required for Myocardial Development
por: Bolte, Craig, et al.
Publicado: (2011)

Periostin as a Heterofunctional Regulator of Cardiac Development and Disease
por: Conway, Simon J, et al.
Publicado: (2008)

A microRNA program regulates the balance between cardiomyocyte hyperplasia and hypertrophy and stimulates cardiac regeneration
por: Raso, Andrea, et al.
Publicado: (2021)

MBNL1-mediated regulation of differentiation RNAs promotes myofibroblast transformation and the fibrotic response
por: Davis, Jennifer, et al.
Publicado: (2015)

A human FLII gene variant alters sarcomeric actin thin filament length and predisposes to cardiomyopathy
por: Kuwabara, Yasuhide, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_0m5u1bujiboe7uj73m2haiq9iv