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The Wnt/β-Catenin Signaling Pathway Controls the Inflammatory Response in Infections Caused by Pathogenic Bacteria

Innate immunity against pathogenic bacteria is critical to protect host cells from invasion and infection as well as to develop an appropriate adaptive immune response. During bacterial infection, different signaling transduction pathways control the expression of a wide range of genes that orchestr...

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Autores principales: Silva-García, Octavio, Valdez-Alarcón, Juan J., Baizabal-Aguirre, Víctor M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127235/
https://www.ncbi.nlm.nih.gov/pubmed/25136145
http://dx.doi.org/10.1155/2014/310183
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author Silva-García, Octavio
Valdez-Alarcón, Juan J.
Baizabal-Aguirre, Víctor M.
author_facet Silva-García, Octavio
Valdez-Alarcón, Juan J.
Baizabal-Aguirre, Víctor M.
author_sort Silva-García, Octavio
collection PubMed
description Innate immunity against pathogenic bacteria is critical to protect host cells from invasion and infection as well as to develop an appropriate adaptive immune response. During bacterial infection, different signaling transduction pathways control the expression of a wide range of genes that orchestrate a number of molecular and cellular events to eliminate the invading microorganisms and regulate inflammation. The inflammatory response must be tightly regulated because uncontrolled inflammation may lead to tissue injury. Among the many signaling pathways activated, the canonical Wnt/β-catenin has been recently shown to play an important role in the expression of several inflammatory molecules during bacterial infections. Our main goal in this review is to discuss the mechanism used by several pathogenic bacteria to modulate the inflammatory response through the Wnt/β-catenin signaling pathway. We think that a deep insight into the role of Wnt/β-catenin signaling in the inflammation may open new venues for biotechnological approaches designed to control bacterial infectious diseases.
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spelling pubmed-41272352014-08-18 The Wnt/β-Catenin Signaling Pathway Controls the Inflammatory Response in Infections Caused by Pathogenic Bacteria Silva-García, Octavio Valdez-Alarcón, Juan J. Baizabal-Aguirre, Víctor M. Mediators Inflamm Review Article Innate immunity against pathogenic bacteria is critical to protect host cells from invasion and infection as well as to develop an appropriate adaptive immune response. During bacterial infection, different signaling transduction pathways control the expression of a wide range of genes that orchestrate a number of molecular and cellular events to eliminate the invading microorganisms and regulate inflammation. The inflammatory response must be tightly regulated because uncontrolled inflammation may lead to tissue injury. Among the many signaling pathways activated, the canonical Wnt/β-catenin has been recently shown to play an important role in the expression of several inflammatory molecules during bacterial infections. Our main goal in this review is to discuss the mechanism used by several pathogenic bacteria to modulate the inflammatory response through the Wnt/β-catenin signaling pathway. We think that a deep insight into the role of Wnt/β-catenin signaling in the inflammation may open new venues for biotechnological approaches designed to control bacterial infectious diseases. Hindawi Publishing Corporation 2014 2014-07-17 /pmc/articles/PMC4127235/ /pubmed/25136145 http://dx.doi.org/10.1155/2014/310183 Text en Copyright © 2014 Octavio Silva-García et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Silva-García, Octavio
Valdez-Alarcón, Juan J.
Baizabal-Aguirre, Víctor M.
The Wnt/β-Catenin Signaling Pathway Controls the Inflammatory Response in Infections Caused by Pathogenic Bacteria
title The Wnt/β-Catenin Signaling Pathway Controls the Inflammatory Response in Infections Caused by Pathogenic Bacteria
title_full The Wnt/β-Catenin Signaling Pathway Controls the Inflammatory Response in Infections Caused by Pathogenic Bacteria
title_fullStr The Wnt/β-Catenin Signaling Pathway Controls the Inflammatory Response in Infections Caused by Pathogenic Bacteria
title_full_unstemmed The Wnt/β-Catenin Signaling Pathway Controls the Inflammatory Response in Infections Caused by Pathogenic Bacteria
title_short The Wnt/β-Catenin Signaling Pathway Controls the Inflammatory Response in Infections Caused by Pathogenic Bacteria
title_sort wnt/β-catenin signaling pathway controls the inflammatory response in infections caused by pathogenic bacteria
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127235/
https://www.ncbi.nlm.nih.gov/pubmed/25136145
http://dx.doi.org/10.1155/2014/310183
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