Cargando…

Effects of a Pragmatic Lifestyle Intervention for Reducing Body Mass in Obese Adults with Obstructive Sleep Apnoea: A Randomised Controlled Trial

This study investigated the effects of a pragmatic lifestyle intervention in obese adults with continuous positive airway pressure-treated obstructive sleep apnoea hypopnoea syndrome (OSAHS). Sixty patients were randomised 1 : 1 to either a 12-week lifestyle intervention or an advice-only control gr...

Descripción completa

Detalles Bibliográficos
Autores principales: Moss, James, Tew, Garry Alan, Copeland, Robert James, Stout, Martin, Billings, Catherine Grant, Saxton, John Michael, Winter, Edward Mitchell, Bianchi, Stephen Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127266/
https://www.ncbi.nlm.nih.gov/pubmed/25136550
http://dx.doi.org/10.1155/2014/102164
_version_ 1782330010566131712
author Moss, James
Tew, Garry Alan
Copeland, Robert James
Stout, Martin
Billings, Catherine Grant
Saxton, John Michael
Winter, Edward Mitchell
Bianchi, Stephen Mark
author_facet Moss, James
Tew, Garry Alan
Copeland, Robert James
Stout, Martin
Billings, Catherine Grant
Saxton, John Michael
Winter, Edward Mitchell
Bianchi, Stephen Mark
author_sort Moss, James
collection PubMed
description This study investigated the effects of a pragmatic lifestyle intervention in obese adults with continuous positive airway pressure-treated obstructive sleep apnoea hypopnoea syndrome (OSAHS). Sixty patients were randomised 1 : 1 to either a 12-week lifestyle intervention or an advice-only control group. The intervention involved supervised exercise sessions, dietary advice, and the promotion of lifestyle behaviour change using cognitive-behavioural techniques. Outcomes were assessed at baseline (week 0), intervention end-point (week 13), and follow-up (week 26). The primary outcome was 13-week change in body mass. Secondary outcomes included anthropometry, blood-borne biomarkers, exercise capacity, and health-related quality of life. At end-point, the intervention group exhibited small reductions in body mass (−1.8 [−3.0, −0.5] kg; P = 0.007) and body fat percentage (−1 [−2, 0]%; P = 0.044) and moderate improvements in C-reactive protein (−1.3 [−2.4, −0.2] mg·L(−1); P = 0.028) and exercise capacity (95 [50, 139] m; P < 0.001). At follow-up, changes in body mass (−2.0 [−3.5, −0.5] kg; P = 0.010), body fat percentage (−1 [−2, 0]%; P = 0.033), and C-reactive protein (−1.3 [−2.5, −0.1] mg·L(−1); P = 0.037) were maintained and exercise capacity was further improved (132 [90, 175] m; P < 0.001). This trial is registered with ClinicalTrials.gov NCT01546792.
format Online
Article
Text
id pubmed-4127266
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-41272662014-08-18 Effects of a Pragmatic Lifestyle Intervention for Reducing Body Mass in Obese Adults with Obstructive Sleep Apnoea: A Randomised Controlled Trial Moss, James Tew, Garry Alan Copeland, Robert James Stout, Martin Billings, Catherine Grant Saxton, John Michael Winter, Edward Mitchell Bianchi, Stephen Mark Biomed Res Int Clinical Study This study investigated the effects of a pragmatic lifestyle intervention in obese adults with continuous positive airway pressure-treated obstructive sleep apnoea hypopnoea syndrome (OSAHS). Sixty patients were randomised 1 : 1 to either a 12-week lifestyle intervention or an advice-only control group. The intervention involved supervised exercise sessions, dietary advice, and the promotion of lifestyle behaviour change using cognitive-behavioural techniques. Outcomes were assessed at baseline (week 0), intervention end-point (week 13), and follow-up (week 26). The primary outcome was 13-week change in body mass. Secondary outcomes included anthropometry, blood-borne biomarkers, exercise capacity, and health-related quality of life. At end-point, the intervention group exhibited small reductions in body mass (−1.8 [−3.0, −0.5] kg; P = 0.007) and body fat percentage (−1 [−2, 0]%; P = 0.044) and moderate improvements in C-reactive protein (−1.3 [−2.4, −0.2] mg·L(−1); P = 0.028) and exercise capacity (95 [50, 139] m; P < 0.001). At follow-up, changes in body mass (−2.0 [−3.5, −0.5] kg; P = 0.010), body fat percentage (−1 [−2, 0]%; P = 0.033), and C-reactive protein (−1.3 [−2.5, −0.1] mg·L(−1); P = 0.037) were maintained and exercise capacity was further improved (132 [90, 175] m; P < 0.001). This trial is registered with ClinicalTrials.gov NCT01546792. Hindawi Publishing Corporation 2014 2014-07-21 /pmc/articles/PMC4127266/ /pubmed/25136550 http://dx.doi.org/10.1155/2014/102164 Text en Copyright © 2014 James Moss et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Moss, James
Tew, Garry Alan
Copeland, Robert James
Stout, Martin
Billings, Catherine Grant
Saxton, John Michael
Winter, Edward Mitchell
Bianchi, Stephen Mark
Effects of a Pragmatic Lifestyle Intervention for Reducing Body Mass in Obese Adults with Obstructive Sleep Apnoea: A Randomised Controlled Trial
title Effects of a Pragmatic Lifestyle Intervention for Reducing Body Mass in Obese Adults with Obstructive Sleep Apnoea: A Randomised Controlled Trial
title_full Effects of a Pragmatic Lifestyle Intervention for Reducing Body Mass in Obese Adults with Obstructive Sleep Apnoea: A Randomised Controlled Trial
title_fullStr Effects of a Pragmatic Lifestyle Intervention for Reducing Body Mass in Obese Adults with Obstructive Sleep Apnoea: A Randomised Controlled Trial
title_full_unstemmed Effects of a Pragmatic Lifestyle Intervention for Reducing Body Mass in Obese Adults with Obstructive Sleep Apnoea: A Randomised Controlled Trial
title_short Effects of a Pragmatic Lifestyle Intervention for Reducing Body Mass in Obese Adults with Obstructive Sleep Apnoea: A Randomised Controlled Trial
title_sort effects of a pragmatic lifestyle intervention for reducing body mass in obese adults with obstructive sleep apnoea: a randomised controlled trial
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127266/
https://www.ncbi.nlm.nih.gov/pubmed/25136550
http://dx.doi.org/10.1155/2014/102164
work_keys_str_mv AT mossjames effectsofapragmaticlifestyleinterventionforreducingbodymassinobeseadultswithobstructivesleepapnoeaarandomisedcontrolledtrial
AT tewgarryalan effectsofapragmaticlifestyleinterventionforreducingbodymassinobeseadultswithobstructivesleepapnoeaarandomisedcontrolledtrial
AT copelandrobertjames effectsofapragmaticlifestyleinterventionforreducingbodymassinobeseadultswithobstructivesleepapnoeaarandomisedcontrolledtrial
AT stoutmartin effectsofapragmaticlifestyleinterventionforreducingbodymassinobeseadultswithobstructivesleepapnoeaarandomisedcontrolledtrial
AT billingscatherinegrant effectsofapragmaticlifestyleinterventionforreducingbodymassinobeseadultswithobstructivesleepapnoeaarandomisedcontrolledtrial
AT saxtonjohnmichael effectsofapragmaticlifestyleinterventionforreducingbodymassinobeseadultswithobstructivesleepapnoeaarandomisedcontrolledtrial
AT winteredwardmitchell effectsofapragmaticlifestyleinterventionforreducingbodymassinobeseadultswithobstructivesleepapnoeaarandomisedcontrolledtrial
AT bianchistephenmark effectsofapragmaticlifestyleinterventionforreducingbodymassinobeseadultswithobstructivesleepapnoeaarandomisedcontrolledtrial