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Clinical Applications of Platelet-Rich Plasma in Patellar Tendinopathy
Platelet-rich plasma (PRP), a blood derivative with high concentrations of platelets, has been found to have high levels of autologous growth factors (GFs), such as transforming growth factor-β (TGF-β), platelet-derived growth factor (PDGF), fibroblastic growth factor (FGF), vascular endothelial gro...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127290/ https://www.ncbi.nlm.nih.gov/pubmed/25136568 http://dx.doi.org/10.1155/2014/249498 |
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author | Jeong, D. U. Lee, C.-R. Lee, J. H. Pak, J. Kang, L.-W. Jeong, B. C. Lee, S. H. |
author_facet | Jeong, D. U. Lee, C.-R. Lee, J. H. Pak, J. Kang, L.-W. Jeong, B. C. Lee, S. H. |
author_sort | Jeong, D. U. |
collection | PubMed |
description | Platelet-rich plasma (PRP), a blood derivative with high concentrations of platelets, has been found to have high levels of autologous growth factors (GFs), such as transforming growth factor-β (TGF-β), platelet-derived growth factor (PDGF), fibroblastic growth factor (FGF), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF). These GFs and other biological active proteins of PRP can promote tissue healing through the regulation of fibrosis and angiogenesis. Moreover, PRP is considered to be safe due to its autologous nature and long-term usage without any reported major complications. Therefore, PRP therapy could be an option in treating overused tendon damage such as chronic tendinopathy. Here, we present a systematic review highlighting the clinical effectiveness of PRP injection therapy in patellar tendinopathy, which is a major cause of athletes to retire from their respective careers. |
format | Online Article Text |
id | pubmed-4127290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41272902014-08-18 Clinical Applications of Platelet-Rich Plasma in Patellar Tendinopathy Jeong, D. U. Lee, C.-R. Lee, J. H. Pak, J. Kang, L.-W. Jeong, B. C. Lee, S. H. Biomed Res Int Review Article Platelet-rich plasma (PRP), a blood derivative with high concentrations of platelets, has been found to have high levels of autologous growth factors (GFs), such as transforming growth factor-β (TGF-β), platelet-derived growth factor (PDGF), fibroblastic growth factor (FGF), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF). These GFs and other biological active proteins of PRP can promote tissue healing through the regulation of fibrosis and angiogenesis. Moreover, PRP is considered to be safe due to its autologous nature and long-term usage without any reported major complications. Therefore, PRP therapy could be an option in treating overused tendon damage such as chronic tendinopathy. Here, we present a systematic review highlighting the clinical effectiveness of PRP injection therapy in patellar tendinopathy, which is a major cause of athletes to retire from their respective careers. Hindawi Publishing Corporation 2014 2014-07-21 /pmc/articles/PMC4127290/ /pubmed/25136568 http://dx.doi.org/10.1155/2014/249498 Text en Copyright © 2014 D. U. Jeong et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Jeong, D. U. Lee, C.-R. Lee, J. H. Pak, J. Kang, L.-W. Jeong, B. C. Lee, S. H. Clinical Applications of Platelet-Rich Plasma in Patellar Tendinopathy |
title | Clinical Applications of Platelet-Rich Plasma in Patellar Tendinopathy |
title_full | Clinical Applications of Platelet-Rich Plasma in Patellar Tendinopathy |
title_fullStr | Clinical Applications of Platelet-Rich Plasma in Patellar Tendinopathy |
title_full_unstemmed | Clinical Applications of Platelet-Rich Plasma in Patellar Tendinopathy |
title_short | Clinical Applications of Platelet-Rich Plasma in Patellar Tendinopathy |
title_sort | clinical applications of platelet-rich plasma in patellar tendinopathy |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127290/ https://www.ncbi.nlm.nih.gov/pubmed/25136568 http://dx.doi.org/10.1155/2014/249498 |
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