Cargando…

Annual Change in Pulmonary Function and Clinical Characteristics of Combined Pulmonary Fibrosis and Emphysema and Idiopathic Pulmonary Fibrosis: Over a 3-Year Follow-up

BACKGROUND: Combined pulmonary fibrosis and emphysema (CPFE) have different pulmonary function tests (PFTs) and outcomes than idiopathic pulmonary fibrosis (IPF). The intention of this study was to identify unknown differences between CPFE and IPF by a retrospective comparison of clinical data inclu...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Yu Jin, Shin, Seong Hyun, Park, Jeong-Woong, Kyung, Sun Young, Kang, Shin Myung, Lee, Sang-Pyo, Sung, Yon Mi, Kim, Yoon Kyung, Jeong, Sung Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Tuberculosis and Respiratory Diseases 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127408/
https://www.ncbi.nlm.nih.gov/pubmed/25114699
http://dx.doi.org/10.4046/trd.2014.77.1.18
_version_ 1782330020686987264
author Kim, Yu Jin
Shin, Seong Hyun
Park, Jeong-Woong
Kyung, Sun Young
Kang, Shin Myung
Lee, Sang-Pyo
Sung, Yon Mi
Kim, Yoon Kyung
Jeong, Sung Hwan
author_facet Kim, Yu Jin
Shin, Seong Hyun
Park, Jeong-Woong
Kyung, Sun Young
Kang, Shin Myung
Lee, Sang-Pyo
Sung, Yon Mi
Kim, Yoon Kyung
Jeong, Sung Hwan
author_sort Kim, Yu Jin
collection PubMed
description BACKGROUND: Combined pulmonary fibrosis and emphysema (CPFE) have different pulmonary function tests (PFTs) and outcomes than idiopathic pulmonary fibrosis (IPF). The intention of this study was to identify unknown differences between CPFE and IPF by a retrospective comparison of clinical data including baseline and annual changes in pulmonary function, comorbidities, laboratory findings, clinical characteristics and cause of hospitalization. METHODS: This study retrospectively enrolled patients with CPFE and IPF who had undergone PFTs once or several times per year during a follow-up period of three years. Baseline clinical characteristics and the annual changes in the pulmonary function during the follow-up period were compared between 26 with CPFE and 42 patients with IPF. RESULTS: The baseline ratio of forced expiratory volume in one second to forced vital capacity (FEV(1)/FVC%) in patients with CPFE was lower than that in patients with IPF (78.6±1.7 vs. 82.9±1.1, p=0.041). The annual decrease in FEV(1)/FVC in the CPFE was significantly higher than in the IPF. The annual decreases in diffusion capacity of carbon monoxide and FVC showed no significant differences between the two groups. The symptom durations of cough and sputum were in the CPFE significantly lower than in the IPF. The serum erythrocyte sedimentation rate level at the acute stage was significantly higher than in the IPF. There were no significant differences in the hospitalization rate and pneumonia was the most common cause of hospitalization in both study groups. CONCLUSION: The annual decrease of FEV(1)/FVC was in patients with CPFE significantly higher than in the patients with IPF.
format Online
Article
Text
id pubmed-4127408
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher The Korean Academy of Tuberculosis and Respiratory Diseases
record_format MEDLINE/PubMed
spelling pubmed-41274082014-08-11 Annual Change in Pulmonary Function and Clinical Characteristics of Combined Pulmonary Fibrosis and Emphysema and Idiopathic Pulmonary Fibrosis: Over a 3-Year Follow-up Kim, Yu Jin Shin, Seong Hyun Park, Jeong-Woong Kyung, Sun Young Kang, Shin Myung Lee, Sang-Pyo Sung, Yon Mi Kim, Yoon Kyung Jeong, Sung Hwan Tuberc Respir Dis (Seoul) Original Article BACKGROUND: Combined pulmonary fibrosis and emphysema (CPFE) have different pulmonary function tests (PFTs) and outcomes than idiopathic pulmonary fibrosis (IPF). The intention of this study was to identify unknown differences between CPFE and IPF by a retrospective comparison of clinical data including baseline and annual changes in pulmonary function, comorbidities, laboratory findings, clinical characteristics and cause of hospitalization. METHODS: This study retrospectively enrolled patients with CPFE and IPF who had undergone PFTs once or several times per year during a follow-up period of three years. Baseline clinical characteristics and the annual changes in the pulmonary function during the follow-up period were compared between 26 with CPFE and 42 patients with IPF. RESULTS: The baseline ratio of forced expiratory volume in one second to forced vital capacity (FEV(1)/FVC%) in patients with CPFE was lower than that in patients with IPF (78.6±1.7 vs. 82.9±1.1, p=0.041). The annual decrease in FEV(1)/FVC in the CPFE was significantly higher than in the IPF. The annual decreases in diffusion capacity of carbon monoxide and FVC showed no significant differences between the two groups. The symptom durations of cough and sputum were in the CPFE significantly lower than in the IPF. The serum erythrocyte sedimentation rate level at the acute stage was significantly higher than in the IPF. There were no significant differences in the hospitalization rate and pneumonia was the most common cause of hospitalization in both study groups. CONCLUSION: The annual decrease of FEV(1)/FVC was in patients with CPFE significantly higher than in the patients with IPF. The Korean Academy of Tuberculosis and Respiratory Diseases 2014-07 2014-07-31 /pmc/articles/PMC4127408/ /pubmed/25114699 http://dx.doi.org/10.4046/trd.2014.77.1.18 Text en Copyright©2014. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved. http://creativecommons.org/licenses/by-nc/3.0/ It is identical to the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/)
spellingShingle Original Article
Kim, Yu Jin
Shin, Seong Hyun
Park, Jeong-Woong
Kyung, Sun Young
Kang, Shin Myung
Lee, Sang-Pyo
Sung, Yon Mi
Kim, Yoon Kyung
Jeong, Sung Hwan
Annual Change in Pulmonary Function and Clinical Characteristics of Combined Pulmonary Fibrosis and Emphysema and Idiopathic Pulmonary Fibrosis: Over a 3-Year Follow-up
title Annual Change in Pulmonary Function and Clinical Characteristics of Combined Pulmonary Fibrosis and Emphysema and Idiopathic Pulmonary Fibrosis: Over a 3-Year Follow-up
title_full Annual Change in Pulmonary Function and Clinical Characteristics of Combined Pulmonary Fibrosis and Emphysema and Idiopathic Pulmonary Fibrosis: Over a 3-Year Follow-up
title_fullStr Annual Change in Pulmonary Function and Clinical Characteristics of Combined Pulmonary Fibrosis and Emphysema and Idiopathic Pulmonary Fibrosis: Over a 3-Year Follow-up
title_full_unstemmed Annual Change in Pulmonary Function and Clinical Characteristics of Combined Pulmonary Fibrosis and Emphysema and Idiopathic Pulmonary Fibrosis: Over a 3-Year Follow-up
title_short Annual Change in Pulmonary Function and Clinical Characteristics of Combined Pulmonary Fibrosis and Emphysema and Idiopathic Pulmonary Fibrosis: Over a 3-Year Follow-up
title_sort annual change in pulmonary function and clinical characteristics of combined pulmonary fibrosis and emphysema and idiopathic pulmonary fibrosis: over a 3-year follow-up
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127408/
https://www.ncbi.nlm.nih.gov/pubmed/25114699
http://dx.doi.org/10.4046/trd.2014.77.1.18
work_keys_str_mv AT kimyujin annualchangeinpulmonaryfunctionandclinicalcharacteristicsofcombinedpulmonaryfibrosisandemphysemaandidiopathicpulmonaryfibrosisovera3yearfollowup
AT shinseonghyun annualchangeinpulmonaryfunctionandclinicalcharacteristicsofcombinedpulmonaryfibrosisandemphysemaandidiopathicpulmonaryfibrosisovera3yearfollowup
AT parkjeongwoong annualchangeinpulmonaryfunctionandclinicalcharacteristicsofcombinedpulmonaryfibrosisandemphysemaandidiopathicpulmonaryfibrosisovera3yearfollowup
AT kyungsunyoung annualchangeinpulmonaryfunctionandclinicalcharacteristicsofcombinedpulmonaryfibrosisandemphysemaandidiopathicpulmonaryfibrosisovera3yearfollowup
AT kangshinmyung annualchangeinpulmonaryfunctionandclinicalcharacteristicsofcombinedpulmonaryfibrosisandemphysemaandidiopathicpulmonaryfibrosisovera3yearfollowup
AT leesangpyo annualchangeinpulmonaryfunctionandclinicalcharacteristicsofcombinedpulmonaryfibrosisandemphysemaandidiopathicpulmonaryfibrosisovera3yearfollowup
AT sungyonmi annualchangeinpulmonaryfunctionandclinicalcharacteristicsofcombinedpulmonaryfibrosisandemphysemaandidiopathicpulmonaryfibrosisovera3yearfollowup
AT kimyoonkyung annualchangeinpulmonaryfunctionandclinicalcharacteristicsofcombinedpulmonaryfibrosisandemphysemaandidiopathicpulmonaryfibrosisovera3yearfollowup
AT jeongsunghwan annualchangeinpulmonaryfunctionandclinicalcharacteristicsofcombinedpulmonaryfibrosisandemphysemaandidiopathicpulmonaryfibrosisovera3yearfollowup